Load flow analysis is an essential tool for the reliable planning and operation of interconnected power systems. The constant increase in power demand, apart from the increased intermittency in power generation due to renewable energy sources without proportionate augmentation in transmission system infrastructure, has driven the power systems to function nearer to their limits. Though the power flow (PF) solution may exist in such circumstances, the traditional Newton–Raphson based PF techniques may fail due to computational difficulties owing to the singularity of the Jacobian Matrix during critical conditions and faces difficulties in solving ill-conditioned systems. To address these problems and to assess the impact of large-scale photovoltaic generator (PVG) integration in power systems on power flow studies, a derivative-free quasi-oppositional heap-based optimization (HBO) (QOHBO) technique is proposed in the present paper. In the proposed approach, the concept of quasi-oppositional learning is applied to HBO to enhance the convergence speed. The efficacy and effectiveness of the proposed QOHBO-PF technique are verified by applying it to the standard IEEE and ill-conditioned systems. The robustness of the algorithm is validated under the maximum loadability limits and high R/X ratios, comparing the results with other well-known methods suggested in the literature. The results thus obtained show that the proposed QOHBO-PF technique has less computation time, further enhancement of reliability in the presence of PVG, and has the ability to provide multiple PF solutions that can be utilized for voltage stability analysis.