This paper offers a comprehensive examination of the development and implementation of advanced safety protocols in the Patient Positioning System (PPS) for radiosurgery. In an era where precision and safety are increasingly crucial in medical procedures, particularly radiosurgery, the implementation of sophisticated safety measures in PPS is vital. This research delves into the detailed design of the system, emphasizing the sensor and controller mechanisms employed. A significant focus is placed on comparing single-loop and dual-loop control systems, assessing their impact on the precision, accuracy, and repeatability of the PPS. The study showcases how dual-loop control demonstrates superior performance in these areas, leading to enhanced patient safety and treatment outcomes. Additionally, the paper discusses the integration of these safety protocols within the system’s architecture, underscoring the practical implications of these advanced measures in augmenting patient safety and treatment effectiveness.