2022
DOI: 10.3389/fbioe.2022.947918
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Application of optical tweezers in cardiovascular research: More than just a measuring tool

Abstract: Recent advances in the field of optical tweezer technology have shown intriguing potential for applications in cardiovascular medicine, bringing this laboratory nanomechanical instrument into the spotlight of translational medicine. This article summarizes cardiovascular system findings generated using optical tweezers, including not only rigorous nanomechanical measurements but also multifunctional manipulation of biologically active molecules such as myosin and actin, of cells such as red blood cells and car… Show more

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Cited by 3 publications
(2 citation statements)
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“…We called this method the “Optical Trapping-Induced Crystallization (OTIC)” method. The OTIC method is based on the principles of the optical tweezer technique (Supporting Information 1), which have evolved into a tool for three-dimensional and noninvasive manipulation and trapping of micrometer or nanometer-scale substances and are currently utilized in various research fields. In the OTIC method, a laser beam is focused on a solution in which the target molecules are dissolved. As a result of the interactions between light and molecules, optical forces (including gradient force and, in the case of surface trapping, scattering force) act on the target molecules, causing multiple molecules to be attracted to the focal volume.…”
Section: Introductionmentioning
confidence: 99%
“…We called this method the “Optical Trapping-Induced Crystallization (OTIC)” method. The OTIC method is based on the principles of the optical tweezer technique (Supporting Information 1), which have evolved into a tool for three-dimensional and noninvasive manipulation and trapping of micrometer or nanometer-scale substances and are currently utilized in various research fields. In the OTIC method, a laser beam is focused on a solution in which the target molecules are dissolved. As a result of the interactions between light and molecules, optical forces (including gradient force and, in the case of surface trapping, scattering force) act on the target molecules, causing multiple molecules to be attracted to the focal volume.…”
Section: Introductionmentioning
confidence: 99%
“…La força aplicada per una pinça òptica és inferior a 1 μN per evitar que la llum danyi les cèl•lules. Per tant, les forces exercides per les pinces òptiques són massa petites per manipular un cardiomiòcit contràctil, cosa que fa que aquest mètode no sigui adequat per al seu ús en cèl•lules cardíaques contràctils(Yadav et al 2021, Yang et al 2022).…”
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