2010
DOI: 10.1016/j.jmr.2010.09.003
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Application of optimal control to CPMG refocusing pulse design

Abstract: We apply optimal control theory (OCT) to the design of refocusing pulses suitable for the CPMG sequence that are robust over a wide range of B(0) and B(1) offsets. We also introduce a model, based on recent progress in the analysis of unitary dynamics in the field of quantum information processing (QIP), that describes the multiple refocusing dynamics of the CPMG sequence as a dephasing Pauli channel. This model provides a compact characterization of the consequences and severity of residual pulse errors. We i… Show more

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Cited by 74 publications
(60 citation statements)
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“…The recent application of optimal control methods to the problem of heteronuclear decoupling yields not only significantly improved performance [377,378] but also unprecedented flexibility in the design of tailored decoupling sequences [379][380][381]. Individual pulses were also optimized for Carr-Purcell-Meiboom-Gill echo train sequences [382,383]. Beyond individually optimized pulses, the simultaneous optimization of pulses provides significant performance gains by exploiting cooperative effects either in a single scan [384] or in multiple scans [385] with first applications in Ramsey-type experiments and in Hahn echo sequences.…”
Section: State Of the Artmentioning
confidence: 99%
See 1 more Smart Citation
“…The recent application of optimal control methods to the problem of heteronuclear decoupling yields not only significantly improved performance [377,378] but also unprecedented flexibility in the design of tailored decoupling sequences [379][380][381]. Individual pulses were also optimized for Carr-Purcell-Meiboom-Gill echo train sequences [382,383]. Beyond individually optimized pulses, the simultaneous optimization of pulses provides significant performance gains by exploiting cooperative effects either in a single scan [384] or in multiple scans [385] with first applications in Ramsey-type experiments and in Hahn echo sequences.…”
Section: State Of the Artmentioning
confidence: 99%
“…in response to the presence of magnetic susceptibility jumps, will significantly improve their performance. In addition to MRI applications, this could be important in production or process monitoring by NMR, where the pulse sequence should be able to adapt to the sample in the same way as shim currents currently do -examples are magnetic susceptibility and tuning variations in imaging, metabolomics and oil well logging [382].…”
Section: Mid-term Prospects: Goals and Challengesmentioning
confidence: 99%
“…In NMR medical imaging [78], hyperpolarized nanoparticles [64] can be used to produce greater image quality at lower concentrations. Since the CPMG sequence has applications in oil well logging [79], its optimization [80] can increase the accuracy with which this can be accomplished. These applications of NMR QIP techniques outside of the field itself further motivate the study and use of NMR systems as quantum information processors.…”
Section: Discussionmentioning
confidence: 99%
“…The de novo design of UR pulses for NMR spectroscopy has received comparatively little attention [9,21], so it is an open question whether the composite constructions using PP pulses achieve the best possible performance. Yet, the demonstrated capabilities of optimal control for designing PP pulses [22,23,24,25,26,27,28,29,30,31,32,33,34,35] are equally applicable to the design of UR pulses [36,37,38]. The required modifications to the basic optimal control algorithm are fairly straightforward [36,39,40] and maintain the same flexibility for incorporating tolerance to variations in experimentally important parameters, such as RF homogeneity or relaxation.…”
Section: Introductionmentioning
confidence: 99%