Application of Organic-Inorganic Hybrids in Chemical Analysis, Bio- and Environmental Monitoring

Silina, Yuliya E.; Gernaey, Krist V.; Semenova, Daria; Iatsunskyi, Igor

doi:10.3390/app10041458

Cited by 25 publications

(18 citation statements)

References 121 publications

(133 reference statements)

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“…Two peaks were found in the RT PL spectrum-a narrow and intense peak at 380 nm and a wide non-symmetric peak, centered at around 520 nm. The PL of ZnO nanostructures usually exhibits near-band-edge (NBE) emissions and the broad deep-level emission (DLE) corresponding to the UV and visible emission, respectively [3]. We have focused on the NBE emission peak (380 nm) intensity as the most informative signal.…”

Section: Zno Nrs Optical Properties After Antibodies Immobilizationmentioning

confidence: 99%

“…Testing concentrations of monoclonal antibodies were selected as 2.5; 5.0; 12.5; 25.0, and 50.0 µg/mL. It is known that covalent and non-covalent interactions formed with different methodologies are used to functionalize the ZnO nanostructures, introducing different organic and functional groups and enhancing the attachment of biomolecules through electrostatic interactions or specific chemical bonds [3]. The simplest method for surface biofunctionalization of metal oxide nanostructures with biomolecules is physical absorption.…”

Section: Zno Nrs Optical Properties After Antibodies Immobilizationmentioning

confidence: 99%

“…Such nanostructures have many unique properties, such as large surface to volume ratio and biocompatibility, that is extremely important for biosensing applications [ 1 ]. One-dimensional metal oxide nanostructures based on ZnO have received great attention for sensing applications because of their simple fabrication procedures, biocompatibility, chemical stability, and significant optical properties, which could be used as a transducer in biosensors development [ 2 , 3 ]. It was demonstrated that zinc oxide-based nanorods (ZnO NRs) are chemically stable and have a high specific surface area, capable of detecting clinically important biomolecules with high sensitivity and reproducibility [ 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods

et al. 2020

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The precise detection of cancer cells currently remains a global challenge. One-dimensional (1D) semiconductor nanostructures (e.g., ZnO nanorods) have attracted attention due to their potential use in cancer biosensors. In the current study, it was demonstrated that the possibility of a photoluminescent detection of human leukemic T-cells by using a zinc oxide nanorods (ZnO NRs) platform. Monoclonal antibodies (MABs) anti-CD5 against a cluster of differentiation (CD) proteins on the pathologic cell surface have been used as a bioselective layer on the ZnO surface. The optimal concentration of the protein anti-CD5 to form an effective bioselective layer on the ZnO NRs surface was selected. The novel biosensing platforms based on glass/ZnO NRs/anti-CD5 were tested towards the human T-lymphoblast cell line MOLT-4 derived from patients with acute lymphoblastic leukemia. The control tests towards MOLT-4 cells were performed by using the glass/ZnO NRs/anti-IgG2a system as a negative control. It was shown that the photoluminescence signal of the glass/ZnO NRs/anti-CD5 system increased after adsorption of T-lymphoblast MOLT-4 cells on the biosensor surface. The increase in the ZnO NRs photoluminescence intensity correlated with the number of CD5-positive MOLT-4 cells in the investigated population (controlled by using flow cytometry). Perspectives of the developed ZnO platforms as an efficient cancer cell biosensor were discussed.

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Section: Zno Nrs Optical Properties After Antibodies Immobilizationmentioning

confidence: 99%

Section: Zno Nrs Optical Properties After Antibodies Immobilizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods

et al. 2020

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“…Moreover, due to its good biocompatibility, low cytotoxicity, high surface to volume ratio with enhanced surface reactivity, and antistatic, antimicrobial, antibacterial, and antifungal properties, ZnO found broad application in biomedicine as a drug carrier, a biomarker for cell labelling, a biosensor, and an antibacterial agent [ 4 , 5 , 6 ]. The material’s functional properties can be achieved by modification of their crystal structure, e.g., by incorporation of impurities into the crystal structure or by surface modification/construction of the materials with the core-shell structure, as well as by obtaining organic/inorganic or inorganic/inorganic composites [ 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications

et al. 2020

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In this study, GNF@ZnO composites (gelatin nanofibers (GNF) with zinc oxide (ZnO) nanoparticles (NPs)) as a novel antibacterial agent were obtained using a wet chemistry approach. The physicochemical characterization of ZnO nanoparticles (NPs) and GNF@ZnO composites, as well as the evaluation of their antibacterial activity toward Gram-positive (Staphyloccocus aureus and Bacillus pumilus) and Gram-negative (Escherichia coli and Pseudomonas fluorescens) bacteria were performed. ZnO NPs were synthesized using a facile sol-gel approach. Gelatin nanofibers (GNF) were obtained by an electrospinning technique. GNF@ZnO composites were obtained by adding previously produced GNF into a Zn2+ methanol solution during ZnO NPs synthesis. Crystal structure, phase, and elemental compositions, morphology, as well as photoluminescent properties of pristine ZnO NPs, pristine GNF, and GNF@ZnO composites were characterized using powder X-ray diffraction (XRD), FTIR analysis, transmission and scanning electron microscopies (TEM/SEM), and photoluminescence spectroscopy. SEM, EDX, as well as FTIR analyses, confirmed the adsorption of ZnO NPs on the GNF surface. The pristine ZnO NPs were highly crystalline and monodispersed with a size of approximately 7 nm and had a high surface area (83 m2/g). The thickness of the pristine gelatin nanofiber was around 1 µm. The antibacterial properties of GNF@ZnO composites were investigated by a disk diffusion assay on agar plates. Results show that both pristine ZnO NPs and their GNF-based composites have the strongest antibacterial properties against Pseudomonas fluorescence and Staphylococcus aureus, with the zone of inhibition above 10 mm. Right behind them is Escherichia coli with slightly less inhibition of bacterial growth. These properties of GNF@ZnO composites suggest their suitability for a range of antimicrobial uses, such as in the food industry or in biomedical applications.

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“…It should not be underestimated that nanomaterials could sense chemicals, toxins, and pathogens in food products. Numerous studies report various nanomaterials, including NPs, nanofibers, and even thin films, to have potential functions as nanobiosensors in food packaging [81]. These nanobiosensors could be placed in food packaging materials to sense alterations in external and internal conditions of food components [79].…”

Section: Type Of Bio-nanocompositementioning

confidence: 99%

Employing Nanosilver, Nanocopper, and Nanoclays in Food Packaging Production: A Systematic Review

et al. 2021

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Over the past decade, there has been an increasing demand for “ready-to-cook” and “ready-to-eat” foods, encouraging food producers, food suppliers, and food scientists to package foods with minimal processing and loss of nutrients during food processing. Following the increasing trend in the customer’s demands for minimally processed foodstuffs, this underscores the importance of promising interests toward industrial applications of novel and practical approaches in food. Along with substantial progress in the emergence of “nanoscience”, which has turned into the call of the century, the efficacy of conventional packaging has faded away. Accordingly, there is a wide range of new types of packaging, including electronic packaging machines, flexible packaging, sterile packaging, metal containers, aluminum foil, and flexographic printing. Hence, it has been demonstrated that these novel approaches can economically improve food safety and quality, decrease the microbial load of foodborne pathogens, and reduce food spoilage. This review study provides a comprehensive overview of the most common chemical or natural nanocomposites used in food packaging that can extend food shelf life, safety and quality. Finally, we discuss applying materials in the production of active and intelligent food packaging nanocomposite, synthesis of nanomaterial, and their effects on human health.

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Application of Organic-Inorganic Hybrids in Chemical Analysis, Bio- and Environmental Monitoring

Cited by 25 publications

References 121 publications

Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods

Photoluminescent Detection of Human T-Lymphoblastic Cells by ZnO Nanorods

Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications

Employing Nanosilver, Nanocopper, and Nanoclays in Food Packaging Production: A Systematic Review

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