Application of ozone in the treatment of periodontal disease

Abstract

Gingivitis and periodontitis are most common inflammatory diseases of supporting tissues of teeth. Role of microbial etiology and host response in progression of gingival and periodontal diseases has been well established. Because of the beneficial biological effects of ozone, due to its antimicrobial and immunostimulating effect, it is well indicated in the treatment of gingival and periodontal diseases. The objective of this article is to provide a general review about clinical applications of ozone in treatment of periodontal diseases and to summarize the available in vitro and in vivo studies in Periodontics in which ozone has been used.

The Effect of Ozone Gel on Bone Matrix Production by Human Osteosarcoma Cell Line Saos-2

“…Our previous reports have elucidated that the same concentration of ozone gel promotes secretion of collagen matrix and suppresses LPS-induced IL-6 and IL-8 expression without exhibiting cytotoxicity to human gingival fi broblasts 20) . Although it is diffi cult to directly link the results of in vitro and in vivo experiments, our results suggest that ozone gas, ozone water, ozone-olive oil 30) , and ozone gel may be used as therapeutic agents for periodontal disease. However, such applications will require detailed evaluation, such as assessment of biological safety using animal models and functional studies on its long-term eff ects in terms of cellular damage.…”

“…Previously, we reported the safety evaluation of ozone for the skin and eye, as well as its antimicrobial eff ects and role in hemostasis using ozone gel [10][11][12] . In addition, a number of reports have shown that ozone can ameliorate periodontal diseases [13][14][15] .…”

Restorati̇f Di̇ş Heki̇mli̇ği̇nde Ozon Tedavi̇leri̇

“…Kanın dokulara oksijen bırakma yeteneğini sağlayan 2,3 DPG (difosfogliserat) miktarında artış meydana gelir. Bu da oksijenin iltihaplı dokuya geri dönmesine imkân tanır 10,13 . Ozon, nitrözoksit gibi damar genişleticilerin salgılanmasına neden olur.…”

Ozon Tedavi̇si̇ni̇n Peri̇odontoloji̇de Kullanimi

“…16 Ozon yüksek konsantrasyonda immün-depresif, düĢük konsantrasyonda ise immünstimülatif etkiye sahiptir. 17 Ozon dolaĢımdaki oksijenin taĢınmasına yardımcı olmaktadır. Süperoksit dismutaz, katalaz, dehidrogenaz, glutatyon peroksidaz enzimleri düĢük dozdaki ozonla aktive olmaktadır.…”