Application of Ozone Therapy in Patients with Knee Osteoarthritis

Calunga, José Luis; Menéndez, Silvia; León, Rodolfo; Chang, Soulien; Guanche, Dailén; Balbín, Alberto; Zayas, J. Gustavo; Garcı́a, Pedro

doi:10.1080/01919512.2012.719120

Cited by 32 publications

(36 citation statements)

References 39 publications

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“…Studies performed in animal models have reported that the application of ozone IA decreases the levels of proinflammatory cytokines and regulates the levels of oxidative stress in synovial fluid, without generating cartilage damage . Furthermore, clinical studies performed in individuals diagnosed with knee OA, have reported similar results, and those findings were accompanied by decreased pain and improvement in functionality …”

Section: Introductionmentioning

confidence: 80%

“…On the other hand, pharmacologic treatment with nonsteroidal antiinflammatory drugs have been evaluated extensively and have shown different levels of effect on knee pain reduction; nevertheless, the presence of adverse reactions vary considerably among treatments and should be used with caution, particularly in patients with increased gastrointestinal risk, elderly patients, and those taking concomitant medication . In contrast, ozone IA could be an alternative to nonsteroidal antiinflammatory drugs when those are contraindicated, as reported by Feng et al Ozone can inhibit inflammatory mediators, reduce the synthesis of prostaglandins, and decrease joint oxidative stress, thereby achieving antiinflammatory and analgesic effects …”

Section: Discussionmentioning

confidence: 99%

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Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

Arias‐Vázquez

Tovilla‐Zárate

Hernández‐Díaz

et al. 2019

PM&R

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Background Ozone therapy has been used widely to decrease pain related to osteoarthritis, but the effectiveness of this treatment has not been evaluated. Objective To evaluate the effectiveness of ozone therapy in the reduction of pain in patients with knee osteoarthritis, according to the type of intervention and duration of the effect. Type Meta‐analysis. Literature Survey We performed an online search using PUBMED, DIALNET, SCIELO, MEDIGRAPHIC, and ISCO3 databases. We searched for articles published up to January 2018. Participants We selected eight studies including a total of 355 patients and 363 controls. Methodology Only randomized‐controlled trials that assessed the efficacy of intraarticular or periarticular infiltrations with ozone to treat knee osteoarthritis in humans were included in the analysis. The results are expressed as standardized mean difference and 95% confidence intervals. The meta‐analysis was performed in accordance with the statement of Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. Synthesis We observed that ozone treatment had a therapeutic effect when compared with placebo (d = −0.81, 95% CI −1.06 to −0.55, I2 = 34.79, P(Q) = .47) or other noninvasive treatments. No significant effects were found in favor of the ozone treatment when compared with the use of hyaluronic acid or platelet‐rich plasma. However, the use of ozone had a significant short‐term benefit reducing knee pain (d = −2.26, 95% CI −2.26 to −3.72, I2 = 97, P(Q) < .001). Pain relief benefits lasted between 3 and 6 months. Conclusion Our results indicate that intraarticular infiltrations of ozone can be used as an optional effective treatment for the management of pain related to knee osteoarthritis. There are short‐term effect benefits that peak at around 1 month of treatment, with a gradual decline in efficacy after 3 to 6 months of treatment. More studies are needed to improve our understanding of the efficacy of this interventional treatment. Level of Evidence I

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Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

Arias‐Vázquez

Tovilla‐Zárate

Hernández‐Díaz

et al. 2019

PM&R

View full text Add to dashboard Cite

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“…ARS Medica Tomitana -2014;1(76):approach, proving to have therapeutically efficient results, thus: antalgic effect by activating the cellular metabolism, it regulates the membrane capacity, it regulates the membrane capacity, it makes the fluids run normally in the inflammated tissues [1], the anti-inflammatory effect, normalizing the intercellular antioxidants and the nitric acid, it helps producing immunomodulation by activating the immunocompetent cells, it also has a protective effect against the endothelial dysfunction [1]; the antiedemic effect, the antioxidant effect makes the redox system function properly by reducing the oxidative stress; it ameliorates the tissue oxygen supply by hemoreologic action, vasodilatation, angiogenesis stimulation and the direct action on the erythrocyte [1]; miorelaxing effect -it reduces the concentration of intracellular calcium and at the level of neuromuscular junction, by reducing the acetylcholine release [2,3,4,5,6].…”

Section: 2478/arsm-2014-0005mentioning

confidence: 99%

The role of ozone therapy in maintaining the articular function and in relieving the pain for patients with knee osteoarthritis

Ciobotaru

Iliescu

Tatiana³

et al. 2014

ARS Medica Tomitana

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Ozone Therapy is thought to be a non-pharmacological therapy, which makes use of oxygen and ozone, It is based on the ozone characteristics, such as the antibacterial and antimycotic, anti-inflammatory and immunomodulatory, of systemic modulation of homeostasy and of the optimization of the way the organs and systems function, but also of tissue bionourishing. Some of the beneficial effects of the ozone are: the enhancement of the oxygen supply in the tissues affected by inflammation and pain, the increase of the blood stream and the removal of the metabolic waste in the joints affected, the obstruction of the substances which maintain the inflammation and pain, an immunomodulatory action upon the whole body, the stimulation of the health improving mechanisms in the body, a mio-relaxing action and thus, a better joint mobility and a better body system functioning.

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“…All these molecules are goals of different drugs and all of them are targets of ozone therapy. Also, a clinical trial in patients with knee osteoarthritis was performed [5]. Osteoarthritis (OA) is defined as a degenerative joint disease that causes pain, stiffness, swelling and loss of motion in the joints which is aggravated by prolonged activity.…”

mentioning

confidence: 99%

“…Also, mitochondrial integrity and functionality was preserved, calcium homeostasis was achieved, adenosine A1 receptors were activated and activity of the superoxide dismutase enzyme was regulated [1]. In this lecture, preclinical and clinical studies of recent researches developed in Cuba are presented.Two topics have been selected: Alcoholism [2,3] and arthritis [4,5].In today's world, alcoholism is a serious health and social problem, affecting millions of people, without distinction of race, sex, culture or latitude. One diagnostic criterion of alcohol dependence is the appearance of a withdrawal syndrome when alcohol consumption ceases.…”

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confidence: 99%

Ozone Therapy: Scientific Updates and Researches in Recent Years

Cepero

2018

J Ozone Ther.

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Ozone medical applications gather strength, day by day. Ozone, in its oxidant status, administered in low doses and in a number of controlled treatments, is able to trigger the endogenous antioxidant systems achieving a redox balance.As such, it is able to control chronic oxidative stress associated with many diseases. Moreover, levels of nitric oxide and pro-inflammatory cytokines, like tumor necrosis factor (TNF-ɑ) and interleukin 1 and 6, were able to be modulated by ozone. Also, mitochondrial integrity and functionality was preserved, calcium homeostasis was achieved, adenosine A1 receptors were activated and activity of the superoxide dismutase enzyme was regulated [1]. In this lecture, preclinical and clinical studies of recent researches developed in Cuba are presented.Two topics have been selected: Alcoholism [2,3] and arthritis [4,5].In today's world, alcoholism is a serious health and social problem, affecting millions of people, without distinction of race, sex, culture or latitude. One diagnostic criterion of alcohol dependence is the appearance of a withdrawal syndrome when alcohol consumption ceases. Experimental studies have demonstrated that many consequences of withdrawal found in animals resemble those observed in humans. Such signs and symptoms of ethanol withdrawal (EW) include enhanced activity of the autonomic nervous system; body posture and motor abnormalities; hyperexcitability of the central nervous system (CNS), including sensory hyperreactivity, convulsion, anxiety, etc. Chronic ingestion of high levels of alcohol may bring about oxidative stress, associated with hepatic alterations, and of CNS, mainly due to the formation, through alcohol metabolism, of free radicals, acetaldehyde, lipid and protein oxidation and their reaction products.The protective effects of ozone on brain injury induced by oxidative stress and behavioral changes in rats, after 2 weeks of EW, were studied [2]. Also, a clinical trial with 10 alcoholic patients (elapsed time after ethanol withdrawal: ≤ 3 weeks) treated with ozone by rectal insufflation (ozone concentration from 20 to 35 mg/L and volumes from 100 to 150 ml) was performed [3]. In the preclinical study [2], 4 groups of rats (n=10 each one) were settled: I-Control, II-Ethanol, III-Ethanol + Ozone (20 mg/L, dose of 1 mg/kg, 10 sessions by rectal insufflation) and IV-Ethanol + Oxygen. At the end of EW, rats were subjected to behavioral tests followed by brain tissue collection to measure markers of oxidative damage. Ozone increased food consumption, maintained water intake at the same levels as the control group and reestablished cellular redox status. Anxiety, locomotor activity and memory/learning of the rats were improved. Ozone protected the brain against oxidative injury, improving important functions of the CNS. In the clinical study [3], the results demonstrated that ozone improved 70% of the signs from Clinical Institute Withdrawal Scale (CIWA-Ar), mainly those associated to CNS. Ozone efficacy was observed in patients that required

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Application of Ozone Therapy in Patients with Knee Osteoarthritis

Cited by 32 publications

References 39 publications

Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

Short‐Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta‐Analysis

The role of ozone therapy in maintaining the articular function and in relieving the pain for patients with knee osteoarthritis

Ozone Therapy: Scientific Updates and Researches in Recent Years

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