Application of PHB-Liposome Particles and Nanofibers in Cosmetics

Abstract

Liposomes are versatile systems for drug delivery. They are utilized in various industries such as pharmaceutical, food industry and cosmetics. Even though they are capable to encapsulate both hydrophilic and lipophilic compounds, they can be modified using cholesterol, proteins and polymers to enhance their properties.Presented work is focused on development and preparation of PHB-liposomes particles with different PHB content as well as PHB nanofibers. Characterization in terms of particle size, polydispersity index, colloidal stability and long-term stability were done. Sun protection factor was measured, too. Electron microscopy techniques (SEM, cryoTEM) were used to observe structure of prepared materials. To assess whether prepared particles are suitable for further application in cosmetics, MTT and LDH cytotoxicity assays on HaCaT cell line were carried out.Our goal was to prepare and characterize PHB containing liposomes and nanofibers for potential application in cosmetic, pharmaceutical and food industry. Prepared particles were stable and had proper properties to be used as vehicles. Cytotoxicity assays showed that all materials were nontoxic to HaCaT cell line and, therefore, they can be ceded for further cytotoxicity as well as genotoxicity testing and in future potentially applicable in cosmetic industry.

The Role of Bacterial Polyhydroalkanoate (PHA) in a Sustainable Future: A Review on the Biological Diversity

“…PHB composites have also been explored in other applications, namely drug delivery and surgical applications [151][152][153][154]. Nanoparticles comprising liposomal particles enriched with PHB have been explored with the perspective to be used in cosmetic products [155].…”