Application of Photo-Realism in Making Gamelan Kenong 3D Objects in Gamelan VR

Kristianto, Stevanus Tetuko; Primasari, Clara Hetty; Sidhi, Thomas Adi Purnomo; Wibisono, Yohanes Priadi; Setyohadi, Djoko Budiyanto

doi:10.26798/jiss.v1i2.758

Cited by 1 publication

(1 citation statement)

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“…This decreased porosity can restrict drug diffusion, leading to slower drug release rates. Since the wound dressings are recommended to be changed within 12 to 48 h [77], we observed the release profile of Ag + and Qu from CS-PE hydrogel films with varying glycerol contents for 48 h only. Interestingly, in the current study, it was observed that while increased glycerol content reduces film porosity (Fig.…”

Section: Release Of Qu and Silver Ions From Cs-pe Films And Skin Perm...mentioning

confidence: 99%

Accelerated full-thickness skin wound tissue regeneration by self-crosslinked chitosan hydrogel films reinforced by oxidized CNC-AgNPs stabilized Pickering emulsion for quercetin delivery

Sharma,

George Joy,

Sharma

et al. 2024

J Nanobiotechnol

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Background The non-toxic self-crosslinked hydrogel films designed from biocompatible materials allow for controlled drug release and have gathered remarkable attention from healthcare professionals as wound dressing materials. Thus, in the current study the chitosan (CS) film is infused with oil-in-water Pickering emulsion (PE) loaded with bioactive compound quercetin (Qu) and stabilized by dialdehyde cellulose nanocrystal-silver nanoparticles (DCNC-AgNPs). The DCNC-AgNPs play a dual role in stabilizing PE and are involved in the self-crosslinking with CS films. Also, this film could combine the advantage of the controlled release and synergistic wound-healing effect of Qu and AgNPs. Results The DCNC-AgNPs were synthesized using sodium periodate oxidation of CNC. The DCNC-AgNPs were used to stabilize oil-in-water PE loaded with Qu in its oil phase by high speed homogenization. Stable PEs were prepared by 20% v/v oil: water ratio with maximum encapsulation of Qu in the oil phase. The Qu-loaded PE was then added to CS solution (50% v/v) to prepare self-crosslinked films (CS-PE-Qu). After grafting CS films with PE, the surface and cross-sectional SEM images show an inter-penetrated network within the matrix between DCNC and CS due to the formation of a Schiff base bond between the reactive aldehyde groups of DCNC-AgNPs and amino groups of CS. Further, the addition of glycerol influenced the extensibility, swelling ratio, and drug release of the films. The fabricated CS-PE-Qu films were analyzed for their wound healing and tissue regeneration potential using cell scratch assay and full-thickness excisional skin wound model in mice. The as-fabricated CS-PE-Qu films showed great biocompatibility, increased HaCat cell migration, and promoted collagen synthesis in HDFa cells. In addition, the CS-PE-Qu films exhibited non-hemolysis and improved wound closure rate in mice compared to CS, CS-Qu, and CS-blank PE. The H&E staining of the wounded skin tissue indicated the wounded tissue regeneration in CS-PE-Qu films treated mice. Conclusion Results obtained here confirm the wound healing benefits of CS-PE-Qu films and project them as promising biocompatible material and well suited for full-thickness wound healing in clinical applications. Graphical Abstract

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Section: Release Of Qu and Silver Ions From Cs-pe Films And Skin Perm...mentioning

confidence: 99%