Application of Physical Methods to Kidney Stones and Randall’s Plaque Characterization

Daudon, Michel; Bazin, Dominique

doi:10.1007/978-1-4471-4387-1_85

Cited by 15 publications

(6 citation statements)

References 76 publications

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“…This was probably since most of the patients had dense and multiple stones and fragments that merit reiteration of ESWL which often persisted after initial ESWL session. This too mirrors the findings reported by recent literature [20].…”

Section: Discussionsupporting

confidence: 92%

Renal Stone Density: Determinant of ESWL Success

Mahar

Fawad

Jawaid

et al. 2022

J. Pharm. Res. Int.

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Background: The worldwide prevalence of developing renal stones is as high as 15% with an estimated 1 in every 5 persons being affected with the condition in Pakistan. Among the many treatment options available for renal calculi, extracorporeal shockwave lithotripsy (ESWL) is among the commonest owing to its non-invasive nature, however, it has its drawbacks; one being limitation against dense stones. Objective: To assess association between stone density (detected on CT KUB) and ESWL outcome among patients with renal calculi. Methodology: This clinical trial was conducted upon a sample of 150 patients (of either gender, aged 16 to 70 years) presenting to the Urology out-patient, emergency and lithotripsy department of Ziauddin University Hospital with renal calculi from 30th August 2017 to 30th September 2019. After taking written informed consent, data was recorded onto a prestructured questionnaire containing inquiries pertaining to basic biodata, sociodemographic details, and disease history, inferences obtained from C.T KUB, operative notes and the eventual treatment outcome. The data obtained was analyzed using SPSS v. 21.0. Results: The mean age of the sample stood at 36.7 (SD ± 3.1). 104 (69.3%) patients had multiple calculi and 46(30.7%) have single calculi with mean density of 812 (SD ± 219) HU. A (having stone density <500-HU) group B (having stone density 501 to 1000-HU) and group C (having stone density >1000-HU). The success of group A was 95.34% group B was 88.5% and group C was 80.3%. Major proportion of the sample (39.3%) required up to 3 ESWL sessions. The stone density was observed to be inversely proportional to the success of ESWL. Conclusion: After careful consideration, it can be concluded that higher stone density is associated with a poor ESWL outcome and thus other treatment modalities may be considered among patients with a stone density of more than 900 HU.

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Section: Discussionsupporting

confidence: 92%

Renal Stone Density: Determinant of ESWL Success

Mahar

Fawad

Jawaid

et al. 2022

J. Pharm. Res. Int.

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“…Experimentally, the following bands are considered as characteristic for whitlockite: 558, 922, 991, 1026, 1078, and 1135 cm −1 . 38 This enables us to propose the following assignments: the 558 cm −1 band might be assigned to a W(OPO) vibration, the 922 cm −1 band to T(OPO), the 991 and 1078 cm −1 bands to ν a (PO), and the 1135 cm −1 band to ν s (PO).…”

Section: ■ Experimental Detailsmentioning

confidence: 99%

One Step Further in the Elucidation of the Crystallographic Structure of Whitlockite

Debroise

Colombo

Belletti

et al. 2020

Crystal Growth & Design

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Whitlockite is a calcium phosphate phase of crucial interest in various pathologies. It appears in abnormal calcification such as dental calculi, kidney stones, or dystrophic calcifications of tuberculous origin. It is a complex material which involves cation substitutions, cation vacancies, and protonation of phosphate groups. In the literature, there is a lack of theoretical characterization of such materials originating from biological calcifications. By means of DFT calculations, we were able to quantify the ability of whitlockite to hold these substitutions and vacancies in preferential sites. The impact of Ca 2+ /Mg 2+ substitutions on characterizations (IR, RAMAN, and XRD) was also investigated in the scope of DFT.

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“…For further insight into the relationship between infection and kidney stones containing Wk without struvite, we have used physicochemical characterization techniques [29][30][31][32] to obtain a precise multiscale description of such concretions [33][34][35][36][37]. First, by analogy with geological studies [38], we assessed the presence of iron in Wk by X-ray fluorescence (XRF) [39][40][41] using synchrotron radiation (SR) as a probe [42][43][44][45][46]. Iron in Wk may modify the position of IR absorption bands and thus may confuse the analysis of IR spectra.…”

Section: Introductionmentioning

confidence: 99%