Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population

Maglalang, Patricia D.; Sinha, Jaydeep; Zimmerman, Kanecia; McCann, Sean; Edginton, Andrea; Hornik, Christoph P.; Hornik, Chi D.; Muller, William J.; Al-Uzri, Amira; Meyer, Marisa; Chen, Jia-Yuh; Anand, Ravinder; Perrin, Eliana M.; Gonzalez, Daniel; ,; Benjamin Jr, Daniel K.; Kennel, Phyllis; Alderman, Cheryl; Sund, Zoe; Opel, Kylie; Beci, Rose; Hornik, Chi Dang; Kearns, Gregory L.; Laughon, Matthew; Paul, Ian M.; Sullivan, Janice; Wade, Kelly; Delmore, Paula; West, Leanne; Abdel-Rahman, Susan; Payne, Elizabeth; Chen, Lily; Simone, Gina; O’Connor, Kathleen; Cermak, Jennifer; Taylor, Lawrence; John, Ramany; Muller, William; Yogev, Ram; Fearn, Laura; Taravath, Sasidharan; Blanks, Tiffony; Lapid, Arielle; Hornik, Chi; Harward, Melissa; Clark, Kira; Craven, Sarah; Grzesek, Kimberly; Joshi, Charuta; Drake, Austin; Filar, Lauri; Sargent, Jennifer; Lakhotia, Arpita; Oldham, Michael; Burmester, Julie; Eubanks, Stephany; Simeon, Terri; Shiloh-Malawsky, Yael; Anderson, Christopher; Jolly, Mallory; Joshi, Shradhdha; Odero, Norbert; Taylor, Jennifer; Arnold, Susan; Harper, Caryn; Howard, Erica; Martinez, Maria; Myer, Deanna; Walker, Angela; Blackford, Martha; Reed, Michael; Hodge, Amanda; Capozzi, Tasha; Anthony, Heather; Stryjewski, Glenn; Klipner, Kimberly; Kowal, Karen; Traisman, Benjamin; Nielsen, Carol; Sroka, Pam; Berkovitch, Matitiahu; Kohn, Elkana; Litalien, Catherine; Autmizguine, Julie; Desmarasis, Diane; Massicotte, Christine; Dumitrascu, Mariana; Lague, Vincent; Goldenberg, Neil; Mourani, Peter; Deschenes, Jendar; DiDomenico, Domninic; Dix, Megan; Halstenson, Gentle; Malone, Kathryn; Ralston, Kimberly; Rutebemberwa, Alleluiah; Sierra, Yamila; Steinbeiss, Matthew; Van, Kevin; McMillan, Hugh; Zemek, Roger; Lacaze, Thierry; Pohl, Daniela; Tuttle, Angie; Murchison, Barbara; Ieradi, Sara; Goldstein, Stuart; Bradley, Gary; Goldstein, Stuart; Mottes, Theresa; Terrell, Tara; Arnold, Patricia; DePaoli, Bradley; Gerhardt, Bradley; Kirby, Cassie; Watt, Kevin; Jefferson, Grace; Baisden, Nicole; Tiedge, Heidi; Milleson, Christie; Wrenn, Samantha; Baez, Anne; Denne, Scott; Poindexter, Brenda; Sokol, Gregory; Kost, Brianne; Moore, Ashley; Deville, Jaime; Shankar, Kavita; Lang, Elizabeth; Finkelstein, Yaron; Rumantir, Maggie; Rathore, Mobeen; Thoma, Kathleen; Borges, Alexandrea; Toltzis, Philip; Speicher, David; Lemon, Eloise; Vitou, Brenna; Goldblatt, Eileen; Adams, Ramon; Tasi, Catherine; Petersen, Lisa; Parsons, Ashlee; James, Laura; Hansberry, Dawn; Hart, Michelle; Howard, Lee; Ann, D Pierce; Sullivan, Janice; Kernen, Karrie; Poff, Susan; Konow, Courtney; Brown, Kelli; Comings, Jen; Michael, Andrew; Perry, Jackie; Wiseheart, Michelle; Laughon, Matthew; Bernhardt, Janice; Mariconti, Ashley; Talbert, Jennifer; Spigarelli, Michael; Sherwin, Catherine; Alger, Fumiko; Narus, JoAnn; Perez, Rebbecca; Rosen, Priscilla; Salman, Yakub; Shakespear, Kaylynn; Shimizu, Joshua; Dixit, Sharada; Delmore, Paula

doi:10.1007/s40262-024-01367-2

Clin Pharmacokinet

2024

DOI: 10.1007/s40262-024-01367-2

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Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population

Patricia D. Maglalang,

Jaydeep Sinha,

Kanecia Zimmerman

et al.

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Coupling Pre- and Postnatal Infant Exposures with Physiologically Based Pharmacokinetic Modeling to Predict Cumulative Maternal Levetiracetam Exposure During Breastfeeding

Suryavanshi,

Wang,

Hajducek

et al. 2024

Clin Pharmacokinet

View full text Add to dashboard Cite

Coupling Pre- and Postnatal Infant Exposures with Physiologically Based Pharmacokinetic Modeling to Predict Cumulative Maternal Levetiracetam Exposure During Breastfeeding

Suryavanshi,

Wang,

Hajducek

et al. 2024

Clin Pharmacokinet

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Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population

Cited by 1 publication

References 43 publications

Coupling Pre- and Postnatal Infant Exposures with Physiologically Based Pharmacokinetic Modeling to Predict Cumulative Maternal Levetiracetam Exposure During Breastfeeding

Coupling Pre- and Postnatal Infant Exposures with Physiologically Based Pharmacokinetic Modeling to Predict Cumulative Maternal Levetiracetam Exposure During Breastfeeding

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