Application of plant-derived exosome-like nanoparticles in drug delivery

Barzin, Mohadeseh; Bagheri, Amir Mohammad; Ohadi, Mandana; Abhaji, Amir Masoud; Salarpour, Soodeh; Dehghannoudeh, Gholamreza

doi:10.1080/10837450.2023.2202242

Cited by 26 publications

(12 citation statements)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the challenges, the unique properties of exosomes have attracted extensive attention of many researchers. Exosomes from plant and milk sources have been explored as a relatively economical alternative option. , In addition, compared to mammals, plants do not carry human pathogens and some plant-derived exosomes carry certain naturally active components. For example, a study found that orally administered ginger-derived exosomes reduced the release of pro-inflammatory factors and promoted intestinal mucosal healing. , It is believed that as these aforementioned issues continue to be addressed and limitations are broken, engineered exosome-based targeted drug delivery systems may become a safe and efficient novel strategy for the clinical treatment of many diseases in the future.…”

Section: Discussionmentioning

confidence: 99%

“…Exosomes from plant and milk sources have been explored as a relatively economical alternative option. 162,163 In addition, compared to mammals, plants do not carry human pathogens and some plant-derived exosomes carry certain naturally active components. For example, a study found that orally administered ginger-derived exosomes reduced the release of pro-inflammatory factors and promoted intestinal mucosal healing.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Research Advances of Engineered Exosomes as Drug Delivery Carrier

Huang,

Wu,

Liao

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Exosomes are nanoscale vesicles secreted by living cells that have similar membrane composition to parental cells and carry a variety of proteins, lipids, and nucleic acids. Therefore, exosomes have certain biological activities and play an important role in intercellular communication. On the basis of its potential as a carrier for drug delivery systems, exosomes have been engineered to compensate for the shortage of natural exosomes through various engineering strategies for improving drug delivery efficiency, enhancing targeting to tissues and organs, and extending the circulating half-life of exosomes. This review focuses on the engineered exosomes loading drugs through different strategies, discussions on exosome surface modification strategies, and summarizes the advantages and disadvantages of different strategies. In addition, this review provides an overview of the recent applications of engineered exosomes in a number of refractory and relapsable diseases. This review has the potential to provide a reference for further research and development of engineered exosomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Research Advances of Engineered Exosomes as Drug Delivery Carrier

Huang,

Wu,

Liao

et al. 2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…148 These findings underscore the potential of plant derived EVs as a novel and promising avenue for drug delivery. [149][150][151]…”

Section: Plant Exosomes-based Cancer Drug Deliverymentioning

confidence: 99%

Plant-derived exosomes: a green approach for cancer drug delivery

Madhan,

Dhar,

Devi

2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…Plant-derived exosome-like nanoparticles (PDELNs) are nanosized vesicles usually isolated from edible fruits or vegetables [ 94 ], which have huge potential for clinical applications compared to exosomes from mammalian cells or bacteria. The highlighted feature of PDELNs includes non/low toxicity, ideal biodistribution, efficient bioavailability, and high yield [ 95 , 96 , 97 ].…”

Section: Plant Derived Exosome-like Nanoparticlesmentioning

confidence: 99%

Emerging Roles of Extracelluar Vesicles Derived from Bacteria, Mammalian or Plant Cells in the Pathogenesis and Clinical Application of Neurodegenerative Diseases

Li,

Zhou,

Liu

et al. 2024

Biomolecules

View full text Add to dashboard Cite

A growing number of studies have indicated that extracellular vesicles (EVs), such as exosomes, are involved in the development of neurodegenerative diseases. Components of EVs with biological effects like proteins, nucleic acids, or other molecules can be delivered to recipient cells to mediate physio-/pathological processes. For instance, some aggregate-prone proteins, such as β-amyloid and α-synuclein, had been found to propagate through exosomes. Therefore, either an increase of detrimental molecules or a decrease of beneficial molecules enwrapped in EVs may fully or partly indicate disease progression. Numerous studies have demonstrated that dysbiosis of the gut microbiota and neurodegeneration are tightly correlated, well-known as the “gut–brain axis”. Accumulating evidence has revealed that the gut bacteria-derived EVs play a pivotal role in mediating microbe–host interactions and affect the function of the “gut–brain axis”, which subsequently contributes to the pathogenesis of neurodegenerative diseases. In this review, we first briefly discuss the role of EVs from mammalian cells and microbes in mediating the progression of neurodegenerative diseases, and then propose a novel strategy that employs EVs of plants (plant cell-derived exosome-like nanoparticles) for treating neurodegeneration.

show abstract

Application of plant-derived exosome-like nanoparticles in drug delivery

Cited by 26 publications

References 151 publications

Research Advances of Engineered Exosomes as Drug Delivery Carrier

Research Advances of Engineered Exosomes as Drug Delivery Carrier

Plant-derived exosomes: a green approach for cancer drug delivery

Emerging Roles of Extracelluar Vesicles Derived from Bacteria, Mammalian or Plant Cells in the Pathogenesis and Clinical Application of Neurodegenerative Diseases

Contact Info

Product

Resources

About