Application of plasma surface modification techniques to improve hemocompatibility of vascular grafts: A review

Abstract

Surface modification using plasma processing can significantly change the chemical and physical characteristics of biomaterial surfaces. When used in combination with additional modification techniques such as direct chemical or biochemical methods, it can produce novel biomaterial surfaces, which are anticoagulant, bioactive, and biomimetic in nature. This article reviews recent advances in improving hemocompatibility of biomaterials by plasma surface modification (PSM). The focus of this review is on PSM of the most commonly used polymers for vascular prostheses such as expanded polytetrafluoroethylene (PTFE), polyethylene terephthalate (Dacron(®) ), and next generation of biomaterials, including polyhedral oligomeric silsesquioxane nanocomposite.

Strategies and Techniques to Enhance theIn SituEndothelialization of Small-Diameter Biodegradable Polymeric Vascular Grafts

“…Plasma surface modification has been utilized significantly in vascular graft engineering to aid in the development of hemocompatible, bioactive, and biomimetic graft surfaces, especially on permanent polymeric grafts. 127 However, it is vital to consider a covalent immobilization technique's effect on biodegradable polymeric grafts. Modification can affect the surface chemistry and aging of polymers, as well as the effective function of the attached biomolecule and the stability of their attachment.…”

Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

“…These have the potential to be used to effectively modulate the cell response (Fu et al 2011;Morent et al 2011;Solouk et al 2011;Vasilev et al 2011;Wu et al 2011a). It is well established that both the stability of cell attachment and the dynamics of the colonisation process differ with surface architecture, chemical composition, and surface energy of the material, and how these compare to the bacterium-specific factors.…”

“…A more economically attractive approach, however, is to enhance materials that are already being used by the medical industry (Raynor et al 2009). Presently, numerous surface modification techniques are under intense investigation for their ability to effectively impart biocompatibility and biofunctionality onto a variety of biomaterials, while preserving their valuable bulk properties and physical dimensionality (Fu et al 2011;Morent et al 2011;Solouk et al 2011;Vasilev et al 2011;Wu et al 2011a). In this review, we will concentrate on the methods currently being used to manipulate the nanoscale surface architecture with a view to imparting bactericidal activity onto the surface, and the effect of these modifications on bacterial attachment and biofilm formation.…”

Preparation of stable polymeric grafted layers on poly(ethylene terephthalate) by thermal annealing

“…The modification of polymeric substrates by grafting is an important route to modify a polymer surface properties and to introduce new functions, for example, biocompatibility 1 , adhesion 2 , friction 3 , lubrication 4 , hydrophobicity 5 , or hydrophilicity 6 , to the substrates. There are two main approaches to graft polymers onto solid surfaces: grafting-from and graftingto 7,8 .…”