Application of PLGA as a Biodegradable and Biocompatible Polymer for Pulmonary Delivery of Drugs

Mahar, Riya; Chakraborty, Arpita; Nainwal, Nidhi; Bahuguna, Richa; Sajwan, Meenakshi; Jakhmola, Vikash

doi:10.1208/s12249-023-02502-1

Cited by 34 publications

(20 citation statements)

References 138 publications

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“…In fact, PLGA was proven to have low immunogenicity, hydrophobicity, biocompatibility, and biodegradability. It was demonstrated to have high efficiency and versatility in the encapsulation of both hydrophilic and hydrophobic factors [ 277 ]. It enhances drug stability (protecting it from degradation) and oral bioavailability, ensures the drug’s prolonged release, and increases its concentration at the site of inflammation, reducing the side effects of toxic molecules.…”

Section: Resultsmentioning

confidence: 99%

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

Garbati,

Picco,

Magrassi

et al. 2024

Pharmaceutics

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The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functions, are thus critical for human health. Targeted drug delivery is essential to tackle these diseases, improve therapy efficacy, and minimize side effects. Recent strategies have taken advantage of both active and passive nanocarriers, which are designed to protect the drug until it reaches the correct delivery site and to modulate drug release via the use of different physical–chemical strategies. In this systematic review, we present a literature overview of the different nanocarriers used for drug delivery in a set of chronic intestinal pathologies, highlighting the rationale behind the controlled release of intestinal therapies. The overall aim is to provide the reader with useful information on the current approaches for gut targeting in novel therapeutic strategies.

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Section: Resultsmentioning

confidence: 99%

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

Garbati,

Picco,

Magrassi

et al. 2024

Pharmaceutics

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“…At present, commonly employed polymer nanoparticles for inhalation formulations include polylactic acid NPs, polylactic acid-polyethylene glycol NPs, polymethyl methacrylate NPs, poly(lactic-co-glycolic acid) (PLGA) NPs and polyvinylpyrrolidone (PVP) NPs. Among them, PLGA is a widely used polymer for inhalable formulations due to its appealing mechanical and processing characteristics ( 67 ). Elbatanony et al ( 68 ) developed biodegradable PLGA nanoparticles loaded with afatinib (AFA), referred to as AFA-NPs, and subsequently evaluated their physicochemical stability.…”

Section: Classification Of Existing Inhalation Formulationsmentioning

confidence: 99%

A novel therapeutic outlook: Classification, applications and challenges of inhalable micron/nanoparticle drug delivery systems in lung cancer (Review)

Xie,

et al. 2024

Int J Oncol

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Lung cancer represents a marked global public health concern. Despite existing treatment modalities, the average 5-year survival rate for patients with patients with lung cancer is only ~20%. As there are numerous adverse effects of systemic administration routes, there is an urgent need to develop a novel therapeutic strategy tailored specifically for patients with lung cancer. Non-invasive aerosol inhalation, as a route of drug administration, holds unique advantages in the context of respiratory diseases. Nanoscale materials have extensive applications in the field of biomedical research in recent years. The present study provides a comprehensive review of the classification, applications summarized according to existing clinical treatment modalities for lung cancer and challenges associated with inhalable micron/nanoparticle drug delivery systems (DDSs) in lung cancer. Achieving localized treatment of lung cancer preclinical models through inhalation is deemed feasible. However, further research is required to substantiate the efficacy and long-term safety of inhalable micron/nanoparticle DDSs in the clinical management of lung cancer.

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“…[105][106][107] Due to its hydrophobicity, biocompatibility, thermoplasticity, easy modification of surface characteristics, adjustable biodegradation rate, and mechanical properties, it has been extensively studied and utilized in drug delivery and tissue engineering. [108][109][110][111][112][113] Studies have shown that PLGA has weak cell adhesion and its acidic degradation products are likely to cause inflammatory responses, 103,114,115 both of which are not conducive to endothelialization and tissue regeneration. However, the hydrophilicity of PLGA can be achieved by attaching different functional groups to modify its surface characteristics, thus improving the interaction with cells and tissues.…”

Section: Poly(lactic-co-glycolic Acid)mentioning

confidence: 99%

“…117 By controlling the lactide/glycolide ratio and molecular weight, the degradation rate and physical properties of PLGA can be adjusted as necessary. 110,114,118,119 In general, PLGA degrades more slowly and has greater mechanical strength when the lactide content is higher in the copolymer. 120,121 In the PCL/PLGA PLGA and Type-I collagen were crosslinked in a 1:1 ratio, and then the nanofibrous matrix membrane of the PLGA/ Type-I collagen blend was produced by electrospinning.…”

Section: Poly(lactic-co-glycolic Acid)mentioning

confidence: 99%

“…In terms of mechanical properties, PLGA has high tensile strength and can be easily fabricated into various shapes and sizes, particularly suitable for cardiac occluders with specially designed structures 117 . By controlling the lactide/glycolide ratio and molecular weight, the degradation rate and physical properties of PLGA can be adjusted as necessary 110,114,118,119 . In general, PLGA degrades more slowly and has greater mechanical strength when the lactide content is higher in the copolymer 120,121 …”

Section: Application Of Biodegradable Polymers In Absorbable Cardiac ...mentioning

confidence: 99%

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Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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Cardiac septal defect is the most prevalent congenital heart disease and is typically treated with open‐heart surgery under cardiopulmonary bypass. Since the 1990s, with the advancement of interventional techniques and minimally invasive transthoracic closure techniques, cardiac occluder implantation represented by the Amplazter products has been the preferred treatment option. Currently, most occlusion devices used in clinical settings are primarily composed of Nitinol as the skeleton. Nevertheless, long‐term follow‐up studies have revealed various complications related to metal skeletons, including hemolysis, thrombus, metal allergy, cardiac erosion, and even severe atrioventricular block. Thus, occlusion devices made of biodegradable materials have become the focus of research. Over the past two decades, several bioabsorbable cardiac occluders for ventricular septal defect and atrial septal defect have been designed and trialed on animals or humans. This review summarizes the research progress of bioabsorbable cardiac occluders, the advantages and disadvantages of different biodegradable polymers used to fabricate occluders, and discusses future research directions concerning the structures and materials of bioabsorbable cardiac occluders.

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Application of PLGA as a Biodegradable and Biocompatible Polymer for Pulmonary Delivery of Drugs

Cited by 34 publications

References 138 publications

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

A novel therapeutic outlook: Classification, applications and challenges of inhalable micron/nanoparticle drug delivery systems in lung cancer (Review)

Progress of biodegradable polymer application in cardiac occluders

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