Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

Abstract

In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107–115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 °C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found.

p(thyme oil) and p(clove oil) organo‐particles with biocompatible, anticancer, antioxidant, and antibacterial properties against Capan‐1 and L‐929 cells

“…Organo‐particles were synthesized as Alpaslan et al [ 10 ] and Ersen Dudu et al applied in the literature. [ 11,12 ] Emulsion polymerization was used to create polymeric organo‐particles of poly(clove Oil) (p(ClO)) and poly(thyme Oil) (p(TO)). Briefly, water, ethanol, and Tween 80 (8:2:1) were mixed in a vial at constant temperature for 10 min.…”

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

“…Hydrogels 20–30 nm in size (“nanogels”) are capable of incorporating hydrophobic drugs into the core and delivering them to their destination, providing their prolonged release. In particular, hydrogel delivery systems for enzymes [ 6 ], proteins [ 7 ], antibiotics [ 8 , 9 , 10 , 11 ], adenoviruses [ 12 ], anticancer drugs, for example, doxorubicin [ 13 , 14 , 15 ], paclitaxel [ 16 ], 5-fluorouracil [ 17 , 18 , 19 ], kaempferol [ 20 ], vincristine [ 21 ], oxaliplatin [ 22 ], cyclophosphamide [ 23 ], carmustine and curcumin [ 24 ], drugs for the treatment of skin diseases [ 25 , 26 , 27 ], anesthetics for the treatment of acute postoperative pain [ 28 ], antimicrobial silver nanoparticles and quantum dots for wound healing [ 29 , 30 ] are known and studied currently. The rate of release of these mentioned drugs from hydrogels is affected by the degree of cross-linking and the degree of swelling of the hydrogels.…”