2023
DOI: 10.3390/molecules28104080
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Application of Polyphenols and Flavonoids in Oncological Therapy

Abstract: The use of naturally derived drugs in anti-cancer therapies has grown exponentially in recent years. Among natural compounds, polyphenols have shown potential therapeutic applications in treatment due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties, resulting in beneficial effects on human health. Building more efficient cancer therapies with fewer side effects on human health can be achieved by combining natural compounds with conventional drugs… Show more

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Cited by 13 publications
(7 citation statements)
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“…[ 19 ] The main groups of polyphenols include flavonoids, phenolic acids, lignands, stilbenes, and curcuminoids. [ 20 ] Flavonoids, being the most abundantly occurring and extensively studied among the polyphenols, demonstrate considerable potential in treating NAFLD due to their inherent safety, widespread availability, and diverse biological activities. [ 21 23 ] The flavonoids identified in this study, namely, quercetin, kaempferol, and naringenin, offer promising advantages in NAFLD treatment through various mechanisms, which is consistent with findings from other studies.…”
Section: Discussionmentioning
confidence: 99%
“…[ 19 ] The main groups of polyphenols include flavonoids, phenolic acids, lignands, stilbenes, and curcuminoids. [ 20 ] Flavonoids, being the most abundantly occurring and extensively studied among the polyphenols, demonstrate considerable potential in treating NAFLD due to their inherent safety, widespread availability, and diverse biological activities. [ 21 23 ] The flavonoids identified in this study, namely, quercetin, kaempferol, and naringenin, offer promising advantages in NAFLD treatment through various mechanisms, which is consistent with findings from other studies.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, untreated HCT-116 cells remained in their identical spindle and angular form. Some detected compounds in the current pollen grains extract, such as naringenin, quercetin, kaempferol, and coumaric acid were reported as anticancer agents in vitro [34]. Maize pollen grains were tested against human prostate cancer by Ganash [28], where at 500 µg/mL, it exhibited 77.09% cytotoxicity with an IC 50 value of 339.81 µg/mL, and the marker changes in the tested cells, such as shrunken and round form, and breakdown of cell DNA were reported.…”
Section: Anticancer Activity Of Pollen Grainsmentioning
confidence: 96%
“…However, the solubility of quercetin derivatives depends on the type of substituent molecules present in the OH group. The O-methyl, C-methyl, and prenyl derivatives of quercetin are lipophilic and are widely found on the surface of leaves, flowers, and fruits of the Labiatae or Compositae families [ 16 ]. Nevertheless, the glycosylation of quercetin increases its hydrophilic properties, and these glycosylated derivatives are soluble in the cytosol of plants, are easily transported to all parts of plants, and are mainly stored in the vacuoles [ 4 ].…”
Section: Quercetin Particularitiesmentioning
confidence: 99%