Application of Porous Polyetheretherketone Scaffold/Vancomycin‐Loaded Thermosensitive Hydrogel Composites for Antibacterial Therapy in Bone Repair

Qi, Desheng; Wang, Ningning; Cheng, Yuanqiang; Zhao, Yao; Meng, Lingcheng; Yue, Xigui; She, Peng; Gao, Hang

doi:10.1002/mabi.202200114

Cited by 14 publications

(8 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The good biocompatibility and suitable degradation time of the Gel were also important for wound treatments besides its thermosensitive feature. 55,56 Cytotoxicity and Intracellular Antioxidative Activity of MOF-818. Prior to evaluating the intracellular antioxidant capability, the cytotoxicity of MOF-818 was tested according to the standard CCK-8 assay.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes

et al. 2022

Self Cite

View full text Add to dashboard Cite

Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments for diabetic chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in chronic wounds is the primary difference between diabetic chronic wounds and normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) for chronic wound healing of diabetic rats through integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species to modulate the oxidative stress microenvironment in diabetic chronic wounds, which leads to a natural transition from the inflammation phase to the proliferation phase. Impressively, the efficacy of one-time-applied MOF/Gel was comparable to that of the human epidermal growth factor Gel, a widely used clinical drug for various wound treatments. Such an effective, safe, and convenient MOF/Gel system can meet complex clinical demands.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

“…As the temperature increased, a sol-to-gel phase transition occurred, which is suitable for its use in wound treatments. The good biocompatibility and suitable degradation time of the Gel were also important for wound treatments besides its thermosensitive feature. , …”

Section: Resultsmentioning

confidence: 99%

Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Qi et al 157 used PLGA–PEG–PLGA thermos-responsive hydrogels loaded with vancomycin on the surface of porous PEEK. It showed high inhibition rate against methicillin-resistant S. aureus in vitro.…”

Section: Surface Modification Substance Coatingsmentioning

confidence: 99%

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Bai,

Zhao,

Cui

et al. 2024

ACS Omega

View full text Add to dashboard Cite

Implant-associated infections and the increasing number of bone implants loosening and falling off after implantation have become urgent global challenges, hence the need for intelligent alternative solutions to combat implant loosening and falling off. The application of polyetheretherketone (PEEK) in biomedical and medical therapy has aroused great interest, especially because its elastic modulus close to bone provides an effective alternative to titanium implants, thereby preventing the possibility of bone implants loosening and falling off due to the mismatch of elastic modulus. In this Review, we provide a comprehensive overview of recent advances in surface modifications to prevent bone binding deficiency and bacterial infection after implantation of bone implants, starting with inorganics for surface modification, followed by organics that can effectively promote bone integration and antimicrobial action. In addition, surface modifications derived from cells and related products of biological activity have been proposed, and there is increasing evidence of clinical potential. Finally, the advantages and future challenges of surface strategies against medical associated poor osseointegration and infection are discussed, with promising prospects for developing novel osseointegration and antimicrobial PEEK materials.

show abstract

“…PLGA has superior biodegradability when compared to other synthetic polymers due to the hydrolysis of ester bonds and auto-catalytic degradation. The hydrophobic PLGA block is usually combined with the hydrophilic PEG block to prepare thermo-responsive hydrogels [ 68 , 69 ].…”

Section: Polymers For Smart Hydrogelsmentioning

confidence: 99%

Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

et al. 2023

View full text Add to dashboard Cite

Rapid and effective repair of injured or diseased bone defects remains a major challenge due to shortages of implants. Smart hydrogels that respond to internal and external stimuli to achieve therapeutic actions in a spatially and temporally controlled manner have recently attracted much attention for bone therapy and regeneration. These hydrogels can be modified by introducing responsive moieties or embedding nanoparticles to increase their capacity for bone repair. Under specific stimuli, smart hydrogels can achieve variable, programmable, and controllable changes on demand to modulate the microenvironment for promoting bone healing. In this review, we highlight the advantages of smart hydrogels and summarize their materials, gelation methods, and properties. Then, we overview the recent advances in developing hydrogels that respond to biochemical signals, electromagnetic energy, and physical stimuli, including single, dual, and multiple types of stimuli, to enable physiological and pathological bone repair by modulating the microenvironment. Then, we discuss the current challenges and future perspectives regarding the clinical translation of smart hydrogels.

show abstract

Application of Porous Polyetheretherketone Scaffold/Vancomycin‐Loaded Thermosensitive Hydrogel Composites for Antibacterial Therapy in Bone Repair

Cited by 14 publications

References 53 publications

Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes

Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

Contact Info

Product

Resources

About