Application of potential probiotic strain Streptomyces sp. SH5 on anti-Aeromonas infection in zebrafish larvae

Liang, Qiting; Liu, Ganxing; Guo, Zheng; Wang, Yuting; Xu, Zhongheng; Ren, Yuxian; Zhang, Qizhong; Cui, Miao; Zhao, Xin-Qing; Xu, Dapeng

doi:10.1016/j.fsi.2022.06.049

Cited by 9 publications

(7 citation statements)

References 51 publications

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“…hydrophila and increased survival in an in vivo tilapia model when challenged (Omar et al 2023 ). Similar results are found when a Streptomyces commensal (Liang et al 2022 ) and a Bacillus commensal (Chen et al 2020 ) were used in a zebrafish model and challenged with A . hydrophila .…”

Section: Qs Inhibition: An Alternative Therapeutic To Antibioticssupporting

confidence: 78%

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Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

Neil,

Cheney,

Rosenzweig

et al. 2024

Appl Microbiol Biotechnol

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Aeromonas species (spp.) are well-known fish pathogens, several of which have been recognized as emerging human pathogens. The organism is capable of causing a wide spectrum of diseases in humans, ranging from gastroenteritis, wound infections, and septicemia to devastating necrotizing fasciitis. The systemic form of infection is often fatal, particularly in patients with underlying chronic diseases. Indeed, recent trends demonstrate rising numbers of hospital-acquired Aeromonas infections, especially in immuno-compromised individuals. Additionally, Aeromonas-associated antibiotic resistance is an increasing challenge in combating both fish and human infections. The acquisition of antibiotic resistance is related to Aeromonas’ innate transformative properties including its ability to share plasmids and integron-related gene cassettes between species and with the environment. As a result, alternatives to antibiotic treatments are desperately needed. In that vein, many treatments have been proposed and studied extensively in the fish-farming industry, including treatments that target Aeromonas quorum sensing. In this review, we discuss current strategies targeting quorum sensing inhibition and propose that such studies empower the development of novel chemotherapeutic approaches to combat drug-resistant Aeromonas spp. infections in humans. Key points • Aeromonas notoriously acquires and maintains antimicrobial resistance, making treatment options limited. • Quorum sensing is an essential virulence mechanism in Aeromonas infections. • Inhibiting quorum sensing can be an effective strategy in combating Aeromonas infections in animals and humans.

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Section: Qs Inhibition: An Alternative Therapeutic To Antibioticssupporting

confidence: 78%

“…hydrophila Fish Increased flora diversity, immune response, and survival in vivo. Downregulated aerA , act , ast , hlyA , alt , and ahyRI expression Liang et al ( 2022 ) Klebsiella and Enterobacter commensals A . hydrophila Fish Decreased AHL production.…”

Section: Qs Inhibition: An Alternative Therapeutic To Antibioticsmentioning

confidence: 99%

Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

Neil,

Cheney,

Rosenzweig

et al. 2024

Appl Microbiol Biotechnol

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show abstract

“…Streptomyces sp. SH5 could enhance the immune responses and increase the expressions of TLR3, lysozyme, and nitric oxide synthase 2α in zebrafish (Liang et al 2022). Through the above studies in zebrafish, we can initially obtain some basic information about the complex interactions of host immunity and intestinal microorganisms, which give us some reference in commercial fish species.…”

Section: The Interactions Between the Host Immunity And Intestinal Mi...mentioning

confidence: 99%

The interactions between the host immunity and intestinal microorganisms in fish

Zhang,

Yang,

Cai

et al. 2024

Appl Microbiol Biotechnol

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There is a huge quantity of microorganisms in the gut of fish, which exert pivotal roles in maintaining host intestinal and general health. The fish immunity can sense and shape the intestinal microbiota and maintain the intestinal homeostasis. In the meantime, the intestinal commensal microbes regulate the fish immunity, control the extravagant proliferation of pathogenic microorganisms, and ensure the intestinal health of the host. This review summarizes developments and progress on the known interactions between host immunity and intestinal microorganisms in fish, focusing on the recent advances in zebrafish (Danio rerio) showing the host immunity senses and shapes intestinal microbiota, and intestinal microorganisms tune host immunity. This review will offer theoretical references for the development, application, and commercialization of intestinal functional microorganisms in fish. Key points • The interactions between the intestinal microorganisms and host immunity in zebrafish• Fish immunity senses and shapes the microbiota • Intestinal microbes tune host immunity in fish

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“…Pretreatment of zebrafish larvae with SH5 effectively inhibited Aeromonas hydrophila colonies by 67.53%. Multiple factors contributed to the SH5 strain’s potential, including an improvement in zebrafish metabolism due to a reduced inflammatory response, repression of virulence factors, a reduction in pathogen colony potential, and improved immune parameters [ 105 ]. Juvenile and adult Artemia treated with Streptomyces cells at 1% concentration (v/v) through bioencapsulation ensued a higher survival rate as compared to the control group after being challenged with Vibrio pathogens at 10 6 CFU/mL [ 77 ].…”

Section: Streptomycesmentioning

confidence: 99%

“…MOE6 In vitro experiment [ 104 ] In vivo protection during challenge experiment Streptomyces sp. SH5 In vitro experiment [ 105 ] Streptomyces CLS-28 Streptomyces CLS-39 Streptomyces CLS-45 Artemia [ 77 ] P. monodon (post-larvae) Streptomyces sp. N7 Streptomyces sp.…”

Section: Streptomycesmentioning

confidence: 99%

Present Status, Limitations, and Prospects of Using Streptomyces Bacteria as a Potential Probiotic Agent in Aquaculture

Butt

Khan

Liu

et al. 2023

Probiotics & Antimicro. Prot.

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Streptomyces is a Gram-positive bacterium, belonging to the family Streptomycetaceae and order Streptomycetales. Several strains from different species of Streptomyces can be used to promote the health and growth of artificially cultured fish and shellfish by producing secondary metabolites including antibiotics, anticancer agents, antiparasitic agents, antifungal agents, and enzymes (protease and amylase). Some Streptomyces strains also exhibit antagonistic and antimicrobial activity against aquaculture-based pathogens by producing inhibitory compounds such as bacteriocins, siderophores, hydrogen peroxide, and organic acids to compete for nutrients and attachment sites in the host. The administration of Streptomyces in aquaculture could also induce an immune response, disease resistance, quorum sensing/antibiofilm activity, antiviral activity, competitive exclusion, modification in gastrointestinal microflora, growth enhancement, and water quality amelioration via nitrogen fixation and degradation of organic residues from the culture system. This review provides the current status and prospects of Streptomyces as potential probiotics in aquaculture, their selection criteria, administrative methods, and mechanisms of action. The limitations of Streptomyces as probiotics in aquaculture are highlighted and the solutions to these limitations are also discussed.

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Application of potential probiotic strain Streptomyces sp. SH5 on anti-Aeromonas infection in zebrafish larvae

Cited by 9 publications

References 51 publications

Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

The interactions between the host immunity and intestinal microorganisms in fish

Present Status, Limitations, and Prospects of Using Streptomyces Bacteria as a Potential Probiotic Agent in Aquaculture

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