Application of Process Capability and Design of Experiments to Improve Quality Parameters

Kumar, Deepak; Kumar, Brijesh; Vinay, M. C.; Yogesh, H. M.; Prabhu, Ashmitha

doi:10.1007/978-981-19-4606-6_45

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Diabetes is a disease characterized by high blood glucose levels, insulin resistance and relative insulin deficiency. [15] In studies on the association of the gut microbiome and DMT2, Akkermansia was shown to be negatively correlated with this disease. [16] A 2021 study by Yun et.…”

Section: Obesitymentioning

confidence: 98%

Akkermansia muciniphila – multifunctional bacteria

Wosińska,

Pazik,

Łopuszyńska

et al. 2023

J Educ Health Sport

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Introduction: The complex symbiotic connection between the host and the gut microbiome, which has many important functions in the organism, provides an opportunity for dysbiosis to potentially serve as a catalyst for various health disorders. Akkermancia muciniphila, a bacterium that degadates mucin, is a noteworthy element of the human gut microbiome and has captured the attention of researchers due to its correlation with numerous diseases. Aim of the study: The purpose of this research was to review literature and determine the impact of Akkermansia muciniphila in selected diseases. A systematic review was conducted using PubMed database. State of knowledge: Studies have shown that reduced numbers of Akkermansia muciniphila have been associated with many diseases, including obesity, type 2 diabetes, atherosclerosis, fatty liver, some neurological conditions, inflammation, and response to cancer immunotherapies. Furthermore, the administration of this bacterium has been shown to have a positive impact on reducing obesity-related parameters, improving insulin sensitivity and glucose homeostasis, mitigating inflammation, and enhancing the prognosis of immune checkpoint inhibitor treatment. Conclusions: The condition and composition of the intestinal microbiome play a significant role in the development and progression of numerous diseases. Akkermansia muciniphila, as demonstrated in various studies, is an example of a bacterium associated with beneficial effects in multiple diseases. It is regarded as a promising candidate for probiotic use.

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Section: Obesitymentioning

confidence: 98%

Akkermansia muciniphila – multifunctional bacteria

Wosińska,

Pazik,

Łopuszyńska

et al. 2023

J Educ Health Sport

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show abstract

“…It is defined as a "genetic disorder of cell growth that is triggered by acquired or less commonly inherited mutations affecting a single cell and its clonal progeny". 2 As reported by GLOBOCAN, breast cancer is ranked as the 1 st most common cancer worldwide, followed by lung cancer. Meanwhile, oral cancer is ranked the 11 th most common cancer worldwide.…”

Section: Introductionmentioning

confidence: 98%

The Association of Sugar and Sugar Substitutes to Breast, Lung, and Oral Cancer Cell Lines: A Scoping Review

Zainal,

Md Asri,

Mohamed Faizal

et al. 2023

imjm

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Cancer which synonymously known as neoplasia is a genetic disorder of cell growth that is triggered by acquired or less commonly inherited mutations affecting a single cell and its clonal progeny. The aims of this scoping review was to investigate the role of sugar and sugar substitutes in breast, lung, and oral cancers with a hypothesis that sugar promoted carcinogenesis. Three databases (EBSCO, PubMed, and Scopus) were searched from January 2010 to December 2021 to identify the preclinical studies eligible for this scoping review. The review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) guidelines. A total of 361 articles were reviewed and the qualitative synthesis used 12 of these articles. Based on the qualitative synthesis, four studies reported dietary sugar (glucose- and/or sucrose) induced cancer progression, one study revealed sugar substitute (aspartame) induced cancer proliferation, seven studies reported that sugar substitutes inhibit cancer proliferation, and one study reported that sucrose promotes cancer while xylitol inhibits cancer. In addition., it was reported that D-allose and cisplatin have a synergistic effect in treating cancer. In conclusion, simple sugar intake is associated with an increased risk of carcinogenesis. In contrast, sugar substitutes inhibit cancer cell line progression, subsequently acting as a potential cancer therapy, thus supporting the study's hypothesis.

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“…CVD encompasses a range of diseases affecting the heart, brain, and body blood vessels, these diseases pose a significant public health threat due to their increasing incidence, imposing substantial burdens on both society and individuals [1]. According to reports from the World Health Organization, CVD claims the lives of approximately 18 million people annually, making it one of the primary global health challenges [2].…”

Section: Introductionmentioning

confidence: 99%

Current studies of cerebral infarction

Zhao

2024

TNS

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Cerebral infarction, also known as stroke, is a serious medical condition resulting from the interruption of blood flow to the brain, either due to blockage or rupture of blood vessels. This interruption leads to localized ischemia and oxygen deprivation in the brain tissue, causing hypoxic-ischemic cell death and subsequent damage to brain function. Cerebral infarction is a leading cause of mortality and morbidity worldwide, particularly among the elderly, but recent research suggests that younger individuals are also increasingly affected. According to reports from the World Health Organization, cardiovascular diseases, including cerebral infarction, account for millions of deaths annually, posing a significant public health threat. The incidence of cerebral infarction among the younger generation is particularly noteworthy, with a significant proportion of patients aged 15-49 suffering from this condition. This trend underscores the need for greater awareness and prevention efforts across all age groups to address this global health challenge.

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Application of Process Capability and Design of Experiments to Improve Quality Parameters

Cited by 4 publications

References 9 publications

Akkermansia muciniphila – multifunctional bacteria

Akkermansia muciniphila – multifunctional bacteria

The Association of Sugar and Sugar Substitutes to Breast, Lung, and Oral Cancer Cell Lines: A Scoping Review

Current studies of cerebral infarction

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