“…As expected, children in the highrisk group were younger; however, they did not differ from the other risk groups in islet autoantibody status or HLA genotype (ESM Table 3). Positive effect sizes represent higher abundance and negative effect sizes represent lower abundance in islet autoantibody-positive vs autoantibody-negative children c Significant differences were reported by Moulder et al [19] d Significant differences were reported by Zhi et al [18] e Significant differences were reported by Zhang et al [17] f Peptides originating from Zhang et al [17], but not selected by dCV in the selection phase of this study g Significant differences were reported by Metz et al [16] h Peptide levels were not significantly different in the Zhang et al [17] validation cohorts ALB, albumin; BTD, biotinidase; C, complement component; CLU, clusterin; CPN1, carboxypeptidase N; EFEMP, epidermal growth factor-containing fibulin-like extracellular matrix protein 1; FN1, fibronectin 1; HPX, haemopexin; ITIH, inter-α-trypsin inhibitor heavy chain; KNG1, kininogen 1; PROZ, vitamin K-dependent protein Z; QSOX1, quiescin Q6 sulfhydryl oxidase 1; SERPINF2, α2-antiplasmin; TTR, transthyretin…”