Application of PRP in Chloasma: A Meta-Analysis and Systematic Review

Abstract

Background. Chloasma is a common skin pigment disorder. Treatment of chloasma has been challenging, often unsatisfactory, and difficult to avoid recurrence. PRP is a new treatment for chloasma, but there is no consensus on its use. Lingyun Zhao’s team recently reported a systematic evaluation and meta-analysis of the efficacy and safety of PRP in the treatment of chloasma, which is consistent with our ideas, but we will elaborate on the application of PRP in chloasma from a deeper and more comprehensive perspective. Before we started this study, we had registered with Prospero as CRD42021233721. Methods. The authors searched the public medical network, MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ScienceDirect, Scopus, and Science Network. The clinical trials registry ClinicalTrials.gov databases were searched for relevant publications to June 2021. The results showed the area and severity of chloasma (MASI) or revised MASI (mMASI) score. Results. Three RCTs, one nonrandomized controlled study, and four were prospective before and after self-controlled studies met the inclusive criteria. Intradermal PRP injections significantly improved chloasma as indicated by the significant decrease MASI (average balance -6.71, 95% CI -8.99 to -4.33) and mMASI scores (average balance -2.94, 95% CI -4.81 to -1.07). The adverse reactions were mild, and there were no significant long-term adverse events. Conclusive. The data can reflect the effectiveness and safety of PRP therapy for chloasma. RCTs are needed to determine effective treatment parameters, and long-term follow-up should be included to better clarify the efficacy and side effects of PRP in treating chloasma.

Effectiveness of the external application of Jidesheng snake tablets, trehalose glycerin mud, and hydroquinone cream in the treatment of melisma

“…Melasma is a yellowish-brown pigmented spot on the face that is not a separate disease but rather a subtype of cutaneous melanosis [8,9]. Despite the lack of a clear etiology, melasma is believed to be caused by a multiplicity of factors, among which genetic susceptibility, sun exposure (ultraviolet rays), and changes in hormone levels are important predisposing factors [10].…”

“…To maintain beauty, some women use cosmetics to cover the spots, but this leads to the further development of melasma [15]. Presently, the primary treatment is the joint use of oral and topical drugs with laser therapy as a complement [8]. However, it should be noted that all these are associated with recurrence, long treatment duration, and high cost.…”

Treatment with injectable platelet-rich fibrin in a rat model of melasma

“…Therefore, novel therapeutic approaches are urgently needed. PRP, a recent approach for treating melasma, has provided significant therapeutic benefits in recent years [13,14], which produces large quantities of growth factors when activated, which can improve pigmentation [15][16][17]. However, several problems are associated with the use of PRP for the treatment of melasma, including the use of anticoagulants, cumbersome preparation steps that may increase the risk of bacterial contamination, and a shorter maintenance period when growth factors are present at higher concentrations due to the fast rate of protein coagulation [18].…”

Clinical evaluation of platelet-rich plasma therapy for osteonecrosis of the femoral head: A systematic review and meta-analysis

“…To better understand PRP therapy efficacy, addressing these limitations in future research is crucial. With the popularization and application of PRP technology, future research needs to be focused on PRP preparation methods, effective concentrations, intervention doses, and methods of use [50,51]. In the future, we can focus on patient's coagulation indices, quality of life, and patient satisfaction, making the results of the study more reliable.…”