Application of quality by design approach to examine the effect of nanocrystalline cellulose extracted from agricultural waste as a disintegrant

Mishra, Shweta; Yadav, Khushwant S.; Prabhakar, Bala

doi:10.1007/s11696-023-03011-y

Cited by 3 publications

(4 citation statements)

References 47 publications

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“…A Box–Behnken design (BBD) was used to generate higher-order response surfaces using fewer required runs than a normal factorial technique. BBD was employed to reduce the complexity as this requires only a few significant points from three-level factorial arrangements . Hence, the total number of experiments needed was 17, and the z-average was used as the response in this study.…”

Section: Methodsmentioning

confidence: 99%

“…BBD was employed to reduce the complexity as this requires only a few significant points from three-level factorial arrangements. 7 Hence, the total number of experiments needed was 17, and the z-average was used as the response in this study. The box is the boundary limit controlled at only 3 level figures as in −1, 0, and +1 to the experimental domain that represents the minimum, optimum, and maximum values.…”

Section: Process Optimization Of Cnc Preparation Using the Design Of ...mentioning

confidence: 99%

“…India is the second largest producer of fruits and vegetables in the world. 7 Lignocellulosic biomass is produced on a large scale yearly during harvesting, cultivation processing, and consumption of agricultural products. Sugarcane is the richest source of sucrose and plays a major role in sugar production globally.…”

Section: Introductionmentioning

confidence: 99%

“…India’s diverse agro climate encourages the cultivation of numerous crops, including medicinal herbs, ornamental plants, decorative plants, vegetables, trees, root tubers, spices, and plantation crops. India is the second largest producer of fruits and vegetables in the world . Lignocellulosic biomass is produced on a large scale yearly during harvesting, cultivation processing, and consumption of agricultural products.…”

Section: Introductionmentioning

confidence: 99%

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New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

Mishra

2024

ACS Omega

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Nanocrystalline cellulose (CNC) has emerged as a subject of researcher’s interest because of its diverse attributes encompassing biocompatibility, sustainability, a high aspect ratio, and an abundance of −OH groups suitable for modifications. Sugarcane bagasse microcrystalline cellulose (SCBMCC) was used as the raw material for the preparation of CNC due to its pure cellulose content, which is mildly compromised by the pectin, hemicellulose, lignin, and other lignocellulosic components. In the present work, CNC was extracted from SCBMCC and used as a disintegrant. The classic hydrolysis technique was used for the preparation of CNC. Hydrolytic conditions were optimized using the response surface methodology (RSM). The optimized batch of CNC was characterized using techniques such as field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Notably, CNC prepared under a hydrolysis time of 90 min exhibited the highest crystallinity of 69.9%. The average particle size and zeta potential were found to be 145 nm and −34.4 mV, respectively. Thermal analysis suggested that an intermediate hydrolysis time resulted in CNC with enhanced thermal stability, showcasing its potential for pharmaceutical applications. Diclofenac potassium was used as the model drug to evaluate the disintegrant properties of CNC as an excipient. Tablets were prepared using the direct compression method. SCBMCC and CNC were used as disintegrants and were compared with the commercial product. The disintegration times (DTs) attained for the tablets prepared using CNC and SCBMCC are 219 and 339.83 s, respectively. The dissolution study of CNC showed a dissolution efficacy (DE%) of 66 and a mean dissolution time (MDT) of 12. The research findings showed that tablets prepared using CNC as disintegrants exhibited the fastest disintegration compared to other formulations.

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Section: Methodsmentioning

confidence: 99%

Section: Process Optimization Of Cnc Preparation Using the Design Of ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

Mishra

2024

ACS Omega

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QbD-based co-loading of paclitaxel and imatinib mesylate by protamine-coated PLGA nanoparticles effective on breast cancer cells

Laxane,

Yadav

2024

Nanomedicine

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Bimatoprost-Loaded Lipidic Nanoformulation Development Using Quality by Design: Liposomes Versus Solid Lipid Nanoparticles in Intraocular Pressure Reduction

Verma,

Singh,

Wadhwa

et al. 2023

Nanomedicine (Lond.)

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Background: Bimatoprost is a drug used to lower intraocular pressure in the treatment of glaucoma. Conventional eye drops have the limitations of repeated dosing, drug loss due to tear outflow and hence poor availability for action. Materials & methods: Using a systematic quality by design approach, liposomes and solid lipid nanoparticles were formulated and further encapsulated in thermosensitive in situ hydrogel. Results & conclusion: Optimized liposomes had 87.04% encapsulation efficiency and 306.78 nm mean particle size, while solid lipid nanoparticles had 90.51% and 304.21 nm. Bimatoprost liposomes had controlled zero-order drug kinetics and no initial burst release, making them better than solid lipid nanoparticles. Bimatoprost-loaded liposomes in thermosensitive hydrogel decreased intraocular pressure for 18 h.

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Application of quality by design approach to examine the effect of nanocrystalline cellulose extracted from agricultural waste as a disintegrant

Cited by 3 publications

References 47 publications

New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

New Excipient For Oral Drug Delivery: CNC Derived From Sugarcane Bagasse-Derived Microcrystalline Cellulose

QbD-based co-loading of paclitaxel and imatinib mesylate by protamine-coated PLGA nanoparticles effective on breast cancer cells

Bimatoprost-Loaded Lipidic Nanoformulation Development Using Quality by Design: Liposomes Versus Solid Lipid Nanoparticles in Intraocular Pressure Reduction

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