2023
DOI: 10.3390/pharmaceutics15071967
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Application of Quality by Design Principles to the Development of Oral Lyophilizates Containing Olanzapine

Abstract: Oral lyophilizates are intended for application to the oral cavity or for dispersing in water. The purposes of this research were: (i) to set up the quality by design approach in the development of oral lyophilizates for drug incorporation; and (ii) to evaluate the established approach by comparing its outcomes with experimentally obtained results. Within the knowledge space, properties about drugs, excipients, and the lyophilization process were acquired, followed by the determination of critical quality attr… Show more

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