In this study, backpropagation neural network (BPNN) and generalized regression neural network (GRNN) approaches are used to predict the frost-heaving ratio (FR) of the saline soil specimen collected from Nong'an, Western Jilin, China. Four variables, namely, water content (WC), compactness, temperature, and content of soluble salts (CSS), are considered in predicting FR. A total of 360 pieces of data, collected from the experimental results, in which 30 pieces of data were selected randomly as the testing set data and the rest of the data were treated as the training set data, are applied to develop the prediction models. The predicted data from the models are compared with the experimental data. Then, the results of the two approaches are compared to obtain a relatively reliable model. Results indicate that the prediction model for the FR of saline soil in Nong'an can be successfully established using the GRNN method. Four new GRNN models are constructed for sensitivity analysis to assess the influence degree of the influencing factors, and the results indicate that water content is the most influential variable in the FR of the saline soil specimen, whereas content of soluble salts is the least influential variable.