Application of reproductive biotechnology in animals: implications and potentials

Paterson, Lesley; DeSousa, Paul; Ritchie, William A.; King, Tim; Wilmut, Ian

doi:10.1016/s0378-4320(03)00161-1

Cited by 45 publications

(21 citation statements)

References 26 publications

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“…An incomplete spermatozoal epigenome, such as one produced from cloning, may be more susceptible to DNA damage and may also be associated with infertility (Aoki et al, 2005;Miller et al, 2010), thus representing a potential threat for embryo development (Paterson et al, 2003). Paternal toxicant exposures may also dysregulate the dynamic regulation of histone modifications in the early embryo.…”

Section: Histone Modifications: Preimplantation Developmentmentioning

confidence: 99%

Epigenetic programming: From gametes to blastocyst

Hales

Grenier

Lalancette

et al. 2011

Birth Defects Research

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Embryo development requires a series of cell fate decisions; cell lineages are established early during development and must be "remembered" through multiple cell divisions. It is increasingly evident that epigenetic marks, DNA methylation, histone modifications, and noncoding RNAs, have a critical role in this cell memory during development. During gametogenesis, epigenetic programming results in the production of spermatozoa and oocytes with distinctive chromatin. The goal of this article is to review what is known about the epigenetic marks in mature gametes and how these marks change during early embryo development. An understanding of the role of epigenetic programming during normal development will lay the basis for the elucidation of its role when development goes awry and the consequence is a birth defect.

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Section: Histone Modifications: Preimplantation Developmentmentioning

confidence: 99%

Epigenetic programming: From gametes to blastocyst

Hales

Grenier

Lalancette

et al. 2011

Birth Defects Research

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“…However, it must be emphasised that current techniques are inadequate to be used safely and efficiently for procreation. In all published research, only a small proportion of embryos produced by using somatic cells developed into live offspring, i.e., typically less than 4% [41]. The low overall success rate is the cumulative result of inefficiencies at each stage of the cloning process.…”

Section: Reproductive Cloningmentioning

confidence: 99%

39. The potential of cryopreservation and reproductive technologies for animal genetic resources conservation strategies

Woelders¹,

Hiemstra²

2011

Cryobiology

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SummaryEx situ conservation of genetic material from livestock and fish through cryopreservation is an important strategy to conserve genetic diversity in these species. Conservation strategies benefit from advances in cryopreservation and reproductive technologies. Choice of type of genetic material to be preserved for different species highly depends on objectives, technical feasibility (e.g., collection, cryoconservation), costs, and practical circumstances. KeywordsLivestock, fish, reproduction, cryopreservation, conservation strategies IntroductionGlobal diversity in domestic animals is considered to be under threat. Worldwide, a large number of domestic animal breeds is endangered, in a critical status or extinct already. Of the 6379 domestic animal breed populations, 9% is in critical condition and 39% is endangered [15]. There is worldwide consensus about the global decline in domestic animal diversity and the need to conserve genetic diversity. The vast majority of aquatic genetic resources are found in wild populations of fish, invertebrates and aquatic plants. Domestication of aquatic species has not proceeded to the same level as it has in crop and livestock sectors. According to FAO, there are more than 1000 common aquatic species that are harvested by humans in major fisheries and thousands of additional species are harvested in small-scale fisheries. The number of species in aquaculture is growing and several important species rely on the collection of brood stock or seed from natural populations. In farm animals, trends in within-breed diversity are as important as between-breed diversity in order to be able to cope with changing requirements and future demands in breeding and selection. A small effective population size in rare or endangered breeds requires monitoring of within-breed diversity and conservation programs to maintain within breed diversity. Several authors also emphasized the reduction in effective population sizes of widely used domestic animal breeds [e.g., 55]. Although introgression of genes for specific traits or characteristics from local breeds to commercial breeds has been very limited so far, Notter [37] suggested that -similar to plants -useful genes may exist in lowly productive types and recommended systematic programs for genetic resources conservation, evaluation and use. There are several options to conserve genetic diversity. In general, in situ conservation or conservation by utilization is preferred as a mechanism to conserve breeds. A breed has to evolve and adapt to changing environments and efforts to create a need for products or functions of the breed should be promoted. Conservation without further development of the breed or without expected future use is not a desirable strategy. However, in addition to in situ

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“…Recent improvements in somatic cell nuclear transfer (SCNT) methodologies have suggested numerous potential applications for cloning in basic research, medicine, and agriculture [109]. Although currently a relatively inefficient process, nuclear transfer using embryo-derived nuclei [110] and fetal and adult cell nuclei [111] has produced viable sheep, including the well-known "Dolly."…”

Section: Somatic Cell Nuclear Transfer Protocols and Cloningmentioning

confidence: 99%

Technical Assessment of the First 20 Years of Research Using Mouse Embryonic Stem Cell Lines

Downing

Battey

2004

STEM CELLS

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This review assesses the effect that mouse embryonic stem (ES) cells have had on biomedical research during the 20 years that followed their isolation in 1981. Notable scientific discoveries enabled by these cell lines-including insights into cell cycle regulation, spatial and temporal relationships during development, and the roles of transcription factors and homeobox genes in developmental pathways-are discussed. The acceleration of basic discovery of gene function and the genetic basis of disease using a breakthrough technology (homologous recombination between modified gene constructs and the ES cell genome) became the principal enabling method to establish transgenic laboratory animals with single targeted genetic change. This review also examines the widespread influence of mouse ES cells as an enabling technology by highlighting their effect on drug development paradigms, directed differentiation to treat specific diseases, nuclear transfer protocols used in cloning, and establishment of methodologies for isolating non-rodent ES cells. This review concludes with a brief analysis of the most influential mouse ES cell lines of the first 20 years as viewed within the twin contexts of human disease application and contributions to the primary literature. Stem

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Application of reproductive biotechnology in animals: implications and potentials

Cited by 45 publications

References 26 publications

Epigenetic programming: From gametes to blastocyst

Epigenetic programming: From gametes to blastocyst

39. The potential of cryopreservation and reproductive technologies for animal genetic resources conservation strategies

Technical Assessment of the First 20 Years of Research Using Mouse Embryonic Stem Cell Lines

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