Application of Response Surface Methodology Using Face-centered Central Composite Design for Studying Long-Term Stability of Gliclazide-Loaded Multiparticulate Systems

Elsayed, Ebtesam W.; Emam, Maha F.

doi:10.1016/j.xphs.2024.03.012

Journal of Pharmaceutical Sciences

2024

DOI: 10.1016/j.xphs.2024.03.012

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Application of Response Surface Methodology Using Face-centered Central Composite Design for Studying Long-Term Stability of Gliclazide-Loaded Multiparticulate Systems

Ebtesam W. Elsayed,

Maha F. Emam

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2024

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Cited by 3 publications

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Mix proportion design based on particle compact packing theory and research on the resistance of metakaolin to chloride salt erosion in UHPC cementitious system

Hong,

Yu,

Sun

et al. 2024

Construction and Building Materials

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Mix proportion design based on particle compact packing theory and research on the resistance of metakaolin to chloride salt erosion in UHPC cementitious system

Hong,

Yu,

Sun

et al. 2024

Construction and Building Materials

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Improved black-winged kite algorithm and finite element analysis for robot parallel gripper design

Haohao,

As’arry,

Yanwei

et al. 2024

Advances in Mechanical Engineering

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This paper presents a comprehensive study on the design optimization of a robotic gripper, focusing on both the gripper modeling and the optimization of its parallel mechanism structure. This study integrates the Black-winged Kite Algorithm (BKA), Finite Element Analysis (FEA), Backpropagation Neural Network (BPNN), and response surface optimization techniques. The Good Point Set (GPS), nonlinear convergence factor, and adaptive t-distribution method improve BKA, which enhances exploration and exploitation performance, convergence speed, and solution quality. Subsequently, the parallel mechanism structure is designed to minimize the total mass, total deformation, and maximum equivalent stress. The central composite design (CCD) method was used to design the FEA experiment and establish the BKA-BPNN regression prediction model. The RMSE of this model’s training set and test set are 0.001615 and 0.0029328. A response surface optimization model is constructed to determine the best design solution. The optimized design achieves a 33.12% reduction in maximum equivalent stress, a 1.47% decrease in total mass, and a 0.16% reduction in maximum total deformation. This study provides valuable insights into the design optimization process for robotic grippers, showcasing the effectiveness of the proposed methodologies in enhancing performance while reducing mass and improving structural integrity.

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Quality by Design (QbD) Approach to Develop Colon-Specific Ketoprofen Hot-Melt Extruded Pellets: Impact of Eudragit® S 100 Coating on the In Vitro Drug Release

Vemula,

Narala,

Uttreja

et al. 2024

Pharmaceutics

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Background: A pelletizer paired with hot-melt extrusion technology (HME) was used to develop colon-targeted pellets for ketoprofen (KTP). Thermal stability and side effects in the upper gastrointestinal tract made ketoprofen more suitable for this work. Methods: The pellets were prepared using the enzyme-triggered polymer Pectin LM in the presence of HPMC HME 4M, followed by pH-dependent Eudragit® S 100 coating to accommodate the maximum drug release in the colon by minimizing drug release in the upper gastrointestinal tract (GIT). Box–Behnken Design (BBD) was used for response surface optimization of the proportion of different independent variables like Pectin LM (A), HPMC HME 4M (B), and Eudragit® S 100 (C) required to lower the early drug release in upper GIT and to extend the drug release in the colon. Results: Solid-state characterization studies revealed that ketoprofen was present in a solid solution state in the hot-melt extruded polymer matrix. The desired responses of the prepared optimized KTP pellets obtained by considering the designed space showed 1.20% drug release in 2 h, 3.73% in the first 5 h of the lag period with the help of Eudragit® S 100 coating, and 93.96% in extended release up to 24 h in the colonic region. Conclusions: Hence, developing Eudragit-coated hot-melt extruded pellets could be a significant method for achieving the colon-specific release of ketoprofen.

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Application of Response Surface Methodology Using Face-centered Central Composite Design for Studying Long-Term Stability of Gliclazide-Loaded Multiparticulate Systems

Cited by 3 publications

References 54 publications

Mix proportion design based on particle compact packing theory and research on the resistance of metakaolin to chloride salt erosion in UHPC cementitious system

Mix proportion design based on particle compact packing theory and research on the resistance of metakaolin to chloride salt erosion in UHPC cementitious system

Improved black-winged kite algorithm and finite element analysis for robot parallel gripper design

Quality by Design (QbD) Approach to Develop Colon-Specific Ketoprofen Hot-Melt Extruded Pellets: Impact of Eudragit® S 100 Coating on the In Vitro Drug Release

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