Application of scanning electrochemical microscopy for topography imaging of supported lipid bilayers

Abstract

The present study demonstrates the application of scanning electrochemical microscopy to follow the morphological changes of the lipid bilayer under oxidative stress or due to the action of membrane proteins or antimicrobial peptides.

Medical gas plasma technology: Roadmap on cancer treatment and immunotherapy

“…In general, it should be noted that gas plasma technology may not only be a therapeutic tool in oncology but can also be used as a multi-ROS technology to study tumor cells’ behavior under short-lived ROS-induced oxidative stress conditions that are more complex and may therefore resemble the in vivo situation much better regarding several biomolecules, including lipids. Apart from computer modeling studies [ [259] , [260] , [261] ] and experimental evidence outside the cancer context [ [262] , [263] , [264] , [265] , [266] , [267] ], the exact role of gas plasma-mediated lipid oxidation and general effects on cell membranes in tumor control is understudied. There is first evidence of a modulation of drug and metabolism-associated membrane transporters following gas plasma exposure [ 72 , 268 , 269 ], but, again, the functional consequences for gas plasma tumor therapy are unknown.…”

Localised Electrochemical Impedance Spectroscopy of Gold Nanoparticles Labelled Antibodies Probed by Platinum Microstructured Ultramicroelectrode

“…SECM is one of the scanning probe microscopy techniques using ultramicroelectrodes (UMEs) as a probe [ 23 ]. This allows the probing of electrochemical processes at the micro- or nano-scale, providing spatially resolved information regarding surface electrochemical reactivity and topography [ 24 , 25 ]. SECM offers the unique ability to locally analyse corrosion, material interfaces, and biological systems.…”

Formation of metal-biomaterials nanocomposites and their application for the development of immunosensors

“…SECM is a versatile surface characterization technique that merges principles of electrochemistry with microscopy and enables the research of materials and interfaces at high spatial resolution. It probes electrochemical processes at the micro-or nanometer scale, providing spatially resolved information about surface electrochemical reactivity and topography (Nasri et al, 2022;Traxler et al, 2022). SECM maps and characterizes surfaces, offering a unique possibility to analyze corrosion, material interfaces, and biological systems locally (Bironaite et al, 2023;Nasri et al, 2022;Traxler et al, 2022).…”

“…It probes electrochemical processes at the micro-or nanometer scale, providing spatially resolved information about surface electrochemical reactivity and topography (Nasri et al, 2022;Traxler et al, 2022). SECM maps and characterizes surfaces, offering a unique possibility to analyze corrosion, material interfaces, and biological systems locally (Bironaite et al, 2023;Nasri et al, 2022;Traxler et al, 2022). Scanning electrochemical microscopy has found applications in fields ranging from fundamental electrochemistry to developing novel materials, biomedical diagnostics, and biosensors, promising insights into complex systems with unparalleled spatial resolution.…”

“…Taip pat nagrinėjama kaip sujungus skenuojamąją elektrocheminę mikroskopiją su elektrocheminio impedanso spektroskopija galima gauti naują analizės metodą, kurį taikant pasirinktoje mėginio vietoje galima išmatuoti elektrocheminį impedansą. Nagrinėjami gautų duomenų vaizdavimo būdai, bei elektrinės ekvivalentinės schemos sudarymo principai (Bironaite et al, 2023;Nasri et al, 2022;Traxler et al, 2022, Sukackienė et al, 2022.…”