Application of SeDeM expert system in formulation and development of fast disintegrating tablets using starch-glycine conjugates as superdisintegrant

Singh, Inderbir; Sharma, Bhawna; Arora, Govind

doi:10.35333/jrp.2019.32

Cited by 6 publications

(9 citation statements)

References 10 publications

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“…For any drug, the pre-compression parameters have been studied in detail to know about the physical property (angle of repose, bulk density, tapped density, compressibility index /Carr's index, Hausner's ratio) of the drug. [10][11][12][13][14]…”

Section: Pre-compression Parametersmentioning

confidence: 99%

Formulation and Evaluation of Ranolazine Fast Dissolving Tablets Using Various Superdisintegrants

Murugesan¹,

Balaraman²,

Krishnamoorthy³

et al. 2023

J. Young Pharm.

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Background: This work is envisaged to understand the use of various superdisintegrants and their drug release effect in the formulation of Ranolazine fast-dissolving tablets (FDTs). Materials and Methods: The FDTs were formulated by using direct compression methods using different superdisintegrants like sodium starch glycolate, croscarmellose sodium and crospovidone. The superdisintegrant's effect at different concentrations was studied with help of precompression studies such as Hausner's ratio, compressibility index, differential scanning calorimetry (DSC) and post-compression studies like friability, disintegration and dissolution studies. Results: The effect of various superdisintegrants on desired drug release was studied and its concentrations were optimized. Based on the evaluation results of various trials, the effective concentration was found to be 15mg/tab of crospovidone. It has a disintegration time of 25 sec and a cumulative percentage drug release of 99.77±0.41. Conclusion: In this study, Ranolazine FDTs were developed and successfully optimized. The ideal superdisintegrant and its concentration were selected. Among the various superdisintegrants, crospovidone was more effective compared to other superdisintegrants. Hence, it is recommended to use crospovidone as an ideal superdisintegrant in the Ranolazine FDTs formulations.

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Section: Pre-compression Parametersmentioning

confidence: 99%

Formulation and Evaluation of Ranolazine Fast Dissolving Tablets Using Various Superdisintegrants

Murugesan¹,

Balaraman²,

Krishnamoorthy³

et al. 2023

J. Young Pharm.

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“…In the range of 0−100, the dissolution profile of the test sample is considered to be identical to that of the reference sample if f 2 ranges from 50 ≤ 100 and f 1 ranges from 0 ≤ 15. 56,57 The obtained in vitro release data from DT-TCM were subjected to fitting to four different kinetic mathematical model-dependent methods; the zero-order, first-order, Higu-…”

Section: In Vitro Dissolution Studymentioning

confidence: 99%

Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Avlani,

Kumar,

H.N

2023

Mol. Pharmaceutics

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Tenofovir disoproxil fumarate (TDF)-loaded bioadhesive chitosan microparticles (CM) were developed by an emulsification internal gelation technique. Among different batches produced, ECH-4 was found to display a high % entrapment efficiency (68.93 ± 1.76%) and sustained drug release of 88.05 ± 0.38% at 24 h. Solid state characterization of ECH-4 employing DSC and PXRD indicated that the TDF existed in an amorphous state as a solid−solid solution in chitosan. Scanning electron microscopy revealed CM of ECH-4 was spherical in shape with a rough surface topography. Laser scattering analysis using Malvern Master sizer indicated that particle size of ECH-4 was in the range of 0.52 ± 0.10 μm to 284.79 ± 21.42 μm with a surface-mean diameter of 12.41 ± 0.06 μm. Ex vivo mucoadhesion studies using rabbit mucosa as a substrate indicated that 10.34 ± 2.08% of CM of ECH-4 was retained at the end of 24 h. The microparticles of ECH-4 were incorporated into dispersible tablets (DT-TCM) intended for intravaginal administration, in view to arrest the preexposure transmission of HIV during sexual intercourse. In vitro release from the dispersible tablet (F3) into simulated vaginal fluid (pH 4.5) displayed a sustained release profile of TDF as 89.98 ± 1.61% of TDF was released at 24 h. The in vitro dissolution profile of the DT-TCM was found to be similar to that of TDF loaded CM with the values of f 1 (difference factor) and f 2 (similarity factor) being 1.52 and 78.02, respectively. Therefore, DT-TCM would be a promising novel drug delivery platform for pre-exposure prophylaxis against HIV.

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“…Adanya gugus amina dan ester pada protected leucine grafted starch (d) [7]. Konjugat pati glisin pada Gambar 6. menunjukkan luas puncak antara 3200-3600 cm -1 dan 1600-1800 cm -1 sesuai dengan gugus asam karboksilat dalam struktur pati dan pembentukan pati konjugat glisin [39]. Berdasarkan Gambar 7. konjugat pati jagung-Neusilin UFL2 yang dibuat dengan metode fisik, microwave mixture, dan kimiawi menunjukan adanya puncak tajam di dekat 3480 cm -1 .…”

Section: Analisis Fourier Transform Infra Red (Ftir)unclassified

“…Gambar 6. Spektrum FTIR Konjugat pati glycine [39] Spektrum FTIR dari polysuccinimide yang ditunjukkan pada Gambar 8. menunjukkan pita tajam pada 1660 cm -1 dan peregangan pada 3500-3700 cm -1 menunjukkan cincin imida dan peregangan N-H. Derivatisasi pati oleh polysuccinimide telah dikonfirmasi dengan adanya puncak pada 1750 cm -1 , dikaitkan dengan pembentukan ikatan sterik dan gugus imida dan amina dari polysuccinimide. Adanya ikatan ester yang baru terbentuk antara gugus hidroksil pati dan gugus karbonil dari rantai polysuccinimide pada 1750 cm -1 [10].…”

Section: Analisis Fourier Transform Infra Red (Ftir)unclassified

Artikel Review: Pengaruh Perlakuan Pada Pati Sebagai Superdisintegran Terhadap Waktu Hancur Fast Disintegrating Tablet

Novita¹,

Fatmawati²

2021

INA RESEARCH PHA

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Pati banyak digunakan dalam formulasi Fast Disintegratating Tablet (FDT) sebagai superdisintegran karena biodegradabilitas dan biokompatibilitasnya, namun beberapa kekurangannya seperti kompresibilitas, sifat alir dan daya serap terhadap air yang rendah dapat membatasi aplikasinya seperti mempengaruhi keseragaman bobot, kesulitan dalam mengempa tablet dan waktu hancur tablet lebih lama. Berbagai modifikasi pati baik secara fisika, kimia, enzimatis maupun kombinasi dilakukan untuk meningkatkan efektivitas penggunaan pati. Tujuan review jurnal ini untuk memberikan informasi mengenai pengaruh perlakuan pada pati dari berbagai sumber sebagai superdisitegran terhadap waktu hancur FDT. Review jurnal ini dilakukan dengan metode literatur review. Pengumpulan data dilakukan melalui elektronik database PubMed dan Google cendekia. Pati hasil modifikasi memiliki permukaan granula pati lebih berpori berdasarkan hasil SEM dibandingkan pati alami. FDT menggunakan superdisintegran pati hasil modifikasi memiliki waktu hancur lebih cepat (<1 menit) dibandingkan pati alami (2-3 menit). Komposisi pati yang digunakan dalam formulasi FDT dapat mempengaruhi waktu hancur tergantung dari sumber pati dan modifikasi pati yang dilakukan. Modifikasi pati secara kimia diantaranya mengkombinasikan pati xanthate dan CMC Na memiliki waktu hancur 12 detik, modifikasi pati beras ikatan silang karboksimetil dengan sodium silikat memiliki waktu hancur 16,83 detik dan modifikasi pati dengan konjugasi glycine memiliki waktu hancur 19 detik merupakan formula yang paling efektif digunakan sebagai superdisintegran dalam formulasi Fast Disintegrating Tablet.

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Application of SeDeM expert system in formulation and development of fast disintegrating tablets using starch-glycine conjugates as superdisintegrant

Abstract: How to cite this article: Singh I, Sharma B, Aora G. Application of SeDeM expert system in formulation and development of fast disintegrating tablets using starch-glycine conjugates as superdisintegrant.

Cited by 6 publications

References 10 publications

Formulation and Evaluation of Ranolazine Fast Dissolving Tablets Using Various Superdisintegrants

Formulation and Evaluation of Ranolazine Fast Dissolving Tablets Using Various Superdisintegrants

Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Artikel Review: Pengaruh Perlakuan Pada Pati Sebagai Superdisintegran Terhadap Waktu Hancur Fast Disintegrating Tablet

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