Application of serum markers in diagnosis and staging of ovarian endometriosis

Abstract

Aims Laparoscopic surgery is widely used for diagnosing ovarian endometriosis but it has medical risks. This study explored the application of blood indicators in diagnosis and staging of ovarian endometriosis, aiming to develop a noninvasive diagnostic method. Methods A total of 190 ovarian endometriosis patients were included in observation group, among these participants, 77 patients among them were stages I–II, and the rest 113 patients were stages III–IV, and a total of 103 healthy women as control group. Serum biochemical indexes, tumor markers, and cytokines levels in two groups were used for the diagnosis and staging of the disease. Area under the receiver operating characteristic (ROC) curve (AUC) predicted the value of individual and joint tests for indicators. Results Biochemical indexes, namely, alkaline phosphatase (ALP), total protein (TP), and glucose (Glu) could distinguish patients from normal women; and that ALP and Glu could indicate disease staging. In tumor markers, alpha fetoprotein (AFP), carcinoembryonic antigen (CA) 125, CA199 and human epididymis protein 4 (HE4) helped to diagnose endometriosis; CA125, HE4, and cytokeratin 19 fragment (CYFRA21‐1) could differentiate stages. In cytokines, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)‐α, interleukin (IL)‐6, soluble fms‐like tyrosine kinase receptor 1 (sflt‐1), monocyte chemoattractant protein (MCP)‐1 therefore, have values to diagnose endometriosis; VEGF, TNF‐α, IL‐6, and sflt‐1 helped to differentiate disease staging. Conclusion Serological indicators in ovarian endometriosis patients were different from healthy women, which were of certain differential values in diagnosis and disease staging. The current study provided a novel strategy for endometriosis diagnosis.

A Clinical Diagnostic Value Analysis of Serum CA125, CA199, and HE4 in Women with Early Ovarian Cancer: Systematic Review and Meta-Analysis

“…After screening, a total of 15 studies were finally included [ 11 – 24 ]. All the included studies were diagnostic tests, including 2262 patients with ovarian cancer, all confirmed by national pathological standards, and the control group included 2300 patients with benign ovarian disease and healthy people, and a total of 4562 cases were included.…”

Treatment of endometriosis with dienogest in combination with traditional Chinese medicine: A systematic review and meta-analysis

“…It has also been shown that VEGF, MMP-2 and MMP-9 are significantly elevated in the serum of patients with endometriosis ( 62 ). In contrast, CA-125 and CA-199 are significantly increased in the serum of patients with endometriosis and together with some other serological indicators can be used as a reference for the early diagnosis and staging of endometriosis ( 63 , 64 ). Some study found that Gal-3 was over-expressed in all forms of endometriosis ( 65 ), it played an important role in the development of endometriosis and might be a target for endometriosis treatment ( 66 ).…”

Association of Tumor Markers with Total Testosterone in the Serum of Women with Polycystic Ovary Syndrome

“…The serum levels of AFP have also been found to be altered in some ovarian lesions. Ting Tang et al [22] observed that the serum levels of AFP in 190 patients with ovarian endometriosis were obviously downward in comparison with 103 healthy subjects. Morever, the value of AFP, CA125, CA199, and HE4 can be combined to distinguish the two groups, with high sensitivity and specificity [22].…”

“…Ting Tang et al [22] observed that the serum levels of AFP in 190 patients with ovarian endometriosis were obviously downward in comparison with 103 healthy subjects. Morever, the value of AFP, CA125, CA199, and HE4 can be combined to distinguish the two groups, with high sensitivity and specificity [22]. A literature review revealed that serum AFP increased in ovarian sertoli-leydig cell tumors [23].…”