Application of serum microRNA-9-5p, 21-5p, and 223-3p combined with tumor markers in the diagnosis of non-small-cell lung cancer in Yunnan in southwestern China

Yang, Yunjun; Chen, Kai; Zhou, Yunyun; Hu, Zaoxiu; Chen, Shuai; Huang, Yunchao

doi:10.2147/ott.s152957

Cited by 35 publications

(19 citation statements)

References 40 publications

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“…Concerning miR-429, its up-regulation in lung adenocarcinoma cell lines was associated with cell proliferation and cell metastasis [ 79 ]. Moreover, circulating microRNAs from liquid biopsy have been proposed as diagnostic and/or prognostic tools in lung cancer [ 80 ]. Among them, elevated serum levels of miR-141, miR-200b, and miR-429 have been proposed as potential biomarkers for early diagnosis in this context [ 81 , 82 ], even though elevation of these microRNAs in blood samples might not be lung specific as it has also been reported in other cancers.…”

Section: Potential Mechanisms Of A-type Lamins Regulation In Lung mentioning

confidence: 99%

Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?

Guinde

Frankel

Perrin

et al. 2018

Cells

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Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of new biomarkers is essential to improve the differential diagnosis between cancer subtypes, to select the most appropriate therapy, and to establish prognostic correlations. Nuclear abnormalities are hallmarks of carcinoma cells and are used as cytological diagnostic criteria of malignancy. Lamins (divided into A- and B-types) are localized in the nuclear matrix comprising nuclear lamina, where they act as scaffolding protein, involved in many nuclear functions, with regulatory effects on the cell cycle and differentiation, senescence and apoptosis. Previous studies have suggested that lamins are involved in tumor development and progression with opposite results concerning their prognostic role. This review provides an overview of lamins expression in lung cancer and the relevance of these findings for disease diagnosis and prognosis. Furthermore, we discuss the link between A-type lamins expression in lung carcinoma cells and nuclear deformability, epithelial to mesenchymal transition, and metastatic potential, and which mechanisms could regulate A-type lamins expression in lung cancer, such as the microRNA miR-9.

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Section: Potential Mechanisms Of A-type Lamins Regulation In Lung mentioning

confidence: 99%

Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?

Guinde

Frankel

Perrin

et al. 2018

Cells

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“…Dysregulated miRNAs may act as tumor suppressors or oncogenes (oncomiRs). Combined serum levels of several miRNAs (miR-9-5p, miR-21-5p, and miR-223-3p) with existing tumor biomarkers offer better detection of NSCLC than the tumor biomarkers alone [10]. Functional studies of dysregulated miRNAs in cancer implicate miRNAs as attractive targets for novel therapeutic development [11, 12].…”

Section: Introductionmentioning

confidence: 99%

miR-25 Promotes Cell Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Targeting the LATS2/YAP Signaling Pathway

Zhang

et al. 2019

Oxidative Medicine and Cellular Longevity

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Metastasis is the leading cause of high mortality in lung cancer patients, and metastatic lung cancer is difficult to treat. miRNAs are involved in various biological processes of cancer, including metastasis. Our previous studies revealed that miR-25 promoted non-small-cell lung cancer (NSCLC) cell proliferation and suppressed cell apoptosis by directly targeting TP53 and MOAP1. In this work, we further explored the miR-25 expression in NSCLC patients in the Cancer Genome Atlas (TCGA) database and measured the miR-25 expression levels in the tissues of NSCLC patients and cell lines. miR-25 was overexpressed in both NSCLC tissues and cell lines. NSCLC patients who expressed a higher level of miR-25 exhibited worse overall survival than those with a lower level of miR-25. Overexpression of miR-25 enhanced NSCLC cell migration and invasion, while the inhibition of miR-25 exhibited the opposite effects. We identified the large tumor suppressor homology 2 (LATS2) as a new target gene of miR-25 in lung cancer. The effects of miR-25 on promoting NSCLC cell migration and invasion were at least partially due to activation of the Hippo signaling pathway. Additionally, miR-25 antagomir inhibited xenograft tumor growth and metastasis by the upregulation of LATS2. Taken together, our findings demonstrate that miR-25 contribute to lung cancer cell proliferation and metastasis by targeting the LATS2/YAP signaling pathway, which implicate miR-25 as a promising therapeutic target for lung cancer metastasis. Given that oxidative stress induces the overexpression of miR-25 and plays a critical role in cancer progression, this study establishes miR-25 as an intermediate between oxidative stress and lung cancer metastasis.

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“…In the referred study, the AUC for miR‐223 was reported to be 0.809 (95% CI: 0.749‐0.860), and its sensitivity and specificity were described to be 69% and 84%, respectively 30 . Yang et al 31 examined the role of serum miR‐223 in NSCLC diagnosis and the AUC was reported to be 0.740 (95% CI: 0.653‐0.816), while the sensitivity and specificity values were not reported. D'Antona et al 32 proposed new aspects of miR‐223 diagnostic performance in patients with NSCLC.…”

Section: Discussionmentioning

confidence: 93%

MicroRNA‐223 in gastrointestinal cancers: A systematic review and diagnostic meta‐analysis

Aalami

Abdeahad

Mesgari

et al. 2020

Eur J Clin Investigation

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Background Several studies have been conducted on the diagnostic role of miR‐223 in cancers related to the digestive system. However, the diagnostic role of this microRNA in gastrointestinal (GI) cancers has not been fully elucidated. This meta‐analysis aimed to accurately assess the diagnostic role of circulating miR‐223 in GI cancers. Methods A literature search was performed in PubMed/Medline, Science Direct, Web of Science, Google Scholar, Embase and Scopus, up to 1st May 2020 databases. Twelve studies were eligible and included in the analysis. Meta‐Disc software was used to calculate the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, area under the curve (AUC) and the summary receiver operating characteristic (SROC) based on true positive, true negative, false negative and false positive for each gastrointestinal cancer separately and in total. Results Twelve case‐control studies were included with 1859 participants (1080 cases and 779 controls). Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 0.77 (95% CI: 0.74‐0.79), 0.75 (95% CI: 0.72‐0.78), 3.04 (95% CI: 2.20‐4.18), 0.31 (95% CI: 0.22‐0.42) and 10.77 (95% CI: 5.96‐19.47), respectively. AUC was 0.83, suggesting a high‐grade diagnostic precision of miR‐223 in gastrointestinal cancers. Besides, subgroup analyses were performed to assess the diagnostic power of miR‐223 based on the type of gastrointestinal cancer, sample type and country via calculating pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio. Conclusion Our meta‐analysis showed the value of circulating miR‐223 levels in the early diagnosis of diverse digestive system carcinomas.

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Application of serum microRNA-9-5p, 21-5p, and 223-3p combined with tumor markers in the diagnosis of non-small-cell lung cancer in Yunnan in southwestern China

Cited by 35 publications

References 40 publications

Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?

Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?

miR-25 Promotes Cell Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Targeting the LATS2/YAP Signaling Pathway

MicroRNA‐223 in gastrointestinal cancers: A systematic review and diagnostic meta‐analysis

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