Application of Several Chromogenic Substrate Assays to Automated Instrumentation for Coagulation Analysis

Bartl, K.; Becker, U.; Lill, H.

doi:10.1055/s-2007-1005030

Cited by 2 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It appeared to be less sus ceptible to the presence of heparin in plasma than the assay described by Kirchhofet al [8], but the reason for this is not clear. The preci sion of the automated assay was superior to that of the manual technique and the CV's obtained were comparable to those obtained with other automated systems [1,2,4,9], Highly significant correlations were ob tained when the assay was compared to the clotting tests which are routinely used for the control of oral anticoagulant therapy. Our estimate of the prothrombin therapeutic range is entirely consistent with that of another study (derived from Thrombotest range 5-12.5%) [10].…”

Section: Discussionsupporting

confidence: 53%

Evaluation of an Automated Prothrombin Assay Using a Chromogenic Substrate

Conkie¹,

McCall²,

Walker³

et al. 1984

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

The performance of a commercially available assay for the determination of prothrombin by a chromogenic substrate method has been evaluated for use on an automated clinical analyser. The method was rapid and simple; accuracy, precision and sensitivity were satisfactory, while carry-over was negligible. Determinations were performed on 170 plasma samples from patients on long-term oral anticoagulant therapy, using the automated amidolytic method; comparison of the prothrombin levels with results obtained by the prothrombin time and Thrombotest methods provided highly significant correlations.

show abstract