Application of smart nanoparticles as a potential platform for effective colorectal cancer therapy

A possible theranostic approach of chitosan-coated iron oxide nanoparticles against human colorectal carcinoma (HCT-116) cell line

“…At the time of PDT, the systemic administration of the photosensitizing light is delivered to the site of tumor growth, which has deeper tissue penetration than visible wavelengths. It would therefore shown to be the safest route for treating metastatic CRC lesions ( Cabeza et al, 2020 ; ( Iranpour et al, 2021 ). The specific delivery of a drug during the course of PDT is the most important phenomena for the therapeutic efficacy because of biomolecular oxidation, triggering the alteration in gene expression regulation ( Castano et al, 2006 , Pan et al, 2007 , Penon et al, 2016 , Weinstein et al, 2010 ).…”

Current status and future prospects of nanoscale metal–organic frameworks in bioimaging

“…Professor Mirzaei In recent years, nanoscale metal-organic frameworks (NMOFs) in the form of attractive drug delivery systems (DDS) have been considerably researched through the achieved developments in nanotechnology, as these materials possess superior physicochemical attributes such as high surface area, large porosity, nanoscale dimension, biodegradability, and facile post-synthesis modification. [18][19][20][21][22] Furthermore, NMOFs have been extensively used in preclinical research because they are applicable as bioimaging agents for the diagnosis of malignant tissues, chronic diseases, and disorders. 23 For example, paramagnetic metal ion-containing MOFs (e.g., Gd 3+ , Mn 2+ , and Fe 3+ ) such as T 1 (as spin-lattice relaxation period) and T 2 (as spin-spin relaxation period) or merged T 1 and T 2 CAs are considered potential candidates for MR imaging.…”

Using magnetic mesoporous silica nanoparticles armed with EpCAM aptamer as an efficient platform for specific delivery of 5-fluorouracil to colorectal cancer cells

“…Generally, SPIONs formed by crystals of iron oxide (magnetite Fe 3 O 4 or maghemite γ-Fe 2 O 3 ) with remarkable physicochemical characteristics such as being non-toxic, and non-immunogenic, having contrast properties, and easy modification, have gained a lot of interest in the field of cancer therapy (Palanisamy and Wang, 2019). Moreover, SPIONs can be coated with various biocompatible polymers in order to improve their colloidal stability and avoid unwanted iron release (Iranpour et al, 2021a). In this regard, MSNs are one of the excellent candidates due to their porous structure, big surface area, good biocompatibility, easy surface functionalization, low toxicity, controllable drug release and low cost (Yang et al, 2019;Kankala et al, 2020a;Kundu et al, 2020;Spoială et al, 2021).…”