Application of soft laser in the treatment of Herpes labialis: Pilot study

Bojović, Marija; Kesić, Ljiljana; Jovanović, Goran; Burić, Nikola; Savić, Zvezdan; Obradoviç, Radmila; Petrović, Milica S.

doi:10.5937/asn1469342b

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…Few other studies have shown that PBM had a signi cant effect on pain reduction of RHL which is similar to our ndings [26-28]. For example, Bojovic et al [29] found that 810-nm PBM could have a signi cant effect on reducing the RHL pain. In contrast to our ndings, Carvalho et al [30] found no signi cant difference in the pain intensity in patients who were treated by laser was lower compared to the patients who were treated by antiviral drug.…”

Section: Discussionsupporting

confidence: 91%

Efficacy of adjuvant Photobiomodulation with Acyclovir in herpes simplex virus type 1 recurrence ulcers treatment, a single-blind randomized clinical trial

Seyyedi,

Gobaran,

yekani

et al. 2023

Preprint

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Objective This study aimed to determine the effect of Photobiomodulation (PBM) in the treatment of recurrent herpes labialis (RHL), one of the most common herpes simplex virus type 1 infections. Material and Methods In this single-blind randomized clinical trial, Twenty-four symptomatic patients with RHL were enrolled. The patients were randomly allocated into the case (received 1% acyclovir cream with PBM 5 times a day for 5 days and control groups who received acyclovir cream similar to the regimen of the treatment group without PBM. The size of the lesions, and pain intensity (based on a visual analogue scale) were considered as the outcome. Results Our findings suggested that, pain intensity 48 hours and 72 hours after treatment in case group were significantly p < 0.001). The lesion’s size was significantly reduced on the 7th and 10th days in the case group (p < 0.05). Patients in the treatment group were significantly more satisfied with their treatment process = group (p = 0.008). Conclusion The results of the present study showed that LLLP in addition with acyclovir cream could be more efficient in treating pain intensity, lesion size, and recovery time in patients treated with recurrent herpes labialis infection. Clinical Relevance: Low laser therapy can be used as an adjuvant therapeutic tool in combination with Acyclovir in patients with Recurrent Herpes Labialis

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Section: Discussionsupporting

confidence: 91%

Efficacy of adjuvant Photobiomodulation with Acyclovir in herpes simplex virus type 1 recurrence ulcers treatment, a single-blind randomized clinical trial

Seyyedi,

Gobaran,

yekani

et al. 2023

Preprint

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Efficacy of low-level laser therapy in management of recurrent herpes labialis: a systematic review

et al. 2018

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Recurrent herpes labialis (RHL) is a highly prevalent viral infection that affects the oro-facial region. Current treatment options have limited efficacy in reducing healing time and recurrence rate of the disease. Recently, low-level laser therapy has been proposed as a potential treatment alternative for the management of RHL with no side effects. This systematic review aims to evaluate the effectiveness of laser therapy in the management and prevention of RHL. A comprehensive search of Medline/PubMed, Scopus, and Web of Science was carried out to identify published clinical trials comparing laser intervention to active and/or non-active controls for the treatment of RHL. Due to marked heterogeneity of available data, studies were assessed qualitatively, and no statistical analysis was performed. Of the retrieved 227 articles, six clinical trials met the eligibility criteria. The wavelengths, the power output, and energy density ranged between 632.5-870 nm, 5-80 W, and 2.04-48 J/cm, respectively. All included studies found laser to be effective in the management and prevention of RHL, without any side effects. The findings of this review suggest that laser is potentially a safe and effective treatment alternative for the management of RHL. However, due to high variability in study designs and inconsistency in laser parameters among the included studies, more well-designed randomized clinical trials with standardized laser parameters are highly warranted.

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Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta-analysis

Barros

Sales

Silva³

et al. 2022

Lasers Med Sci

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Application of soft laser in the treatment of Herpes labialis: Pilot study

Cited by 6 publications

References 16 publications

Efficacy of adjuvant Photobiomodulation with Acyclovir in herpes simplex virus type 1 recurrence ulcers treatment, a single-blind randomized clinical trial

Efficacy of adjuvant Photobiomodulation with Acyclovir in herpes simplex virus type 1 recurrence ulcers treatment, a single-blind randomized clinical trial

Efficacy of low-level laser therapy in management of recurrent herpes labialis: a systematic review

Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta-analysis

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