Application of solid-phase microextraction and gas chromatography–mass spectrometry for the determination of chlorophenols in urine

Lee, Maw-Rong; Yeh, Y. C.; Hsiang, W. S.; Chen, Chih‐Cheng

doi:10.1016/s0378-4347(97)00611-7

Cited by 56 publications

(21 citation statements)

References 20 publications

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“…Based on a signal-to-noise ratio S/N=3, the LOD was evaluated under GC-ECD conditions. In this paper, the value of LOD was found to be in the range of 0.3-0.5 μg/L, generally comparable to those US Environment Protection Agency (EPA) method 604 (7.4 μg/L) [13] . To determine the LOD, syringe blanks were carried out every time to confirm that no sample carryover occurred.…”

Section: Limit Of Detectionsupporting

confidence: 66%

Application of LPME/GC-ECD for determination of PCP in water

Liu

2003

Sc. China Ser. B-Chem.

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Liquid-phase microextraction (LPME) followed by gas chromatography (GC) coupled with an electron capture detector (ECD) was applied for the analysis of pentachlorophenol (PCP) in aqueous samples. After alkalization with Na 2 CO 3 solution, PCP was acetylated with acetic anhydride. The pentachlorophenyl acetate derivative was then extracted with n-hexane by LPME. 1.5 μL organic drop exposed to the aqueous sample solution at 15℃ for 5 min, stirring rate at 100 r/min was chosen as the optimum extraction condition. Under this condition, LPME provided a very simple, fast and solvent-less procedure to collect PCP from aqueous sample for GC determination. The linearity of LPME/GC-ECD for PCP in distilled water was investigated at the range of 2-200 μg/L with a coefficient of correlation 0.998. The repeatability of this method was determined at the level of 50 μg/L with the average of relative standard deviations (RSDs) 7%. Detection limit was obtained at less than 0.5 μg/L levels. When LPME/GC-ECD was applied to the determination of PCP in municipal sewage, the average of relative recoveries and RSDs were 70% and 6.5%, respectively.

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Section: Limit Of Detectionsupporting

confidence: 66%

Application of LPME/GC-ECD for determination of PCP in water

Liu

2003

Sc. China Ser. B-Chem.

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“…The widespread application of SPME is attributed for its solventfree feature, it is simple to use, it combines analyte extraction and pre-concentration in a single process allowing direct desorption in the chromatographic system. The extraction of analytes in SPME depends on the absorbent coating of the fibre, as well as on experimental parameters, like time and temperature of extraction, and matrix composition [13].…”

Section: Introductionmentioning

confidence: 99%

Profiling allergic asthma volatile metabolic patterns using a headspace-solid phase microextraction/gas chromatography based methodology

Caldeira

Barros

Bilelo³

et al. 2011

Journal of Chromatography A

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a b s t r a c tAllergic asthma represents an important public health issue with significant growth over the years, especially in the paediatric population. Exhaled breath is a non-invasive, easily performed and rapid method for obtaining samples from the lower respiratory tract. In the present manuscript, the metabolic volatile profiles of allergic asthma and control children were evaluated by headspace solid-phase microextraction combined with gas chromatography-quadrupole mass spectrometry (HS-SPME/GC-qMS). The lack of studies in breath of allergic asthmatic children by HS-SPME led to the development of an experimental design to optimize SPME parameters. To fulfil this objective, three important HS-SPME experimental parameters that influence the extraction efficiency, namely fibre coating, temperature and time extractions were considered. The selected conditions that promoted higher extraction efficiency corresponding to the higher GC peak areas and number of compounds were: DVB/CAR/PDMS coating fibre, 22 • C and 60 min as the extraction temperature and time, respectively. The suitability of two containers, 1 L Tedlar ® bags and BIOVOC ® , for breath collection and intra-individual variability were also investigated. The developed methodology was then applied to the analysis of children exhaled breath with allergic asthma (35), from which 13 had also allergic rhinitis, and healthy control children (15), allowing to identify 44 volatiles distributed over the chemical families of alkanes (linear and ramified) ketones, aromatic hydrocarbons, aldehydes, acids, among others. Multivariate studies were performed by Partial Least Squares-Discriminant Analysis (PLS-DA) using a set of 28 selected metabolites and discrimination between allergic asthma and control children was attained with a classification rate of 88%. The allergic asthma paediatric population was characterized mainly by the compounds linked to oxidative stress, such as alkanes and aldehydes. Furthermore, more detailed information was achieved combining the volatile metabolic data, suggested by PLS-DA model, and clinical data.

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“…Therefore, the composition and structure of the coating materials play an essential role for SPME technique. So far, a variety of coatings such as polydimethylsiloxane (PDMS) [10,11], polyacrylate [12,13], PDMS (DVB) [14] are commercially available. Nevertheless, these polymeric coatings generally exhibit some disadvantages such as relatively low operating temperature (240e280 C) [15], instability in organic solvents [16] and the stripping of coatings [17], which hinder their further applications.…”

Section: Introductionmentioning

confidence: 99%

Ordered mesoporous carbon film as an effective solid-phase microextraction coating for determination of benzene series from aqueous media

Jiang

et al. 2015

Analytica Chimica Acta

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Application of solid-phase microextraction and gas chromatography–mass spectrometry for the determination of chlorophenols in urine

Cited by 56 publications

References 20 publications

Application of LPME/GC-ECD for determination of PCP in water

Application of LPME/GC-ECD for determination of PCP in water

Profiling allergic asthma volatile metabolic patterns using a headspace-solid phase microextraction/gas chromatography based methodology

Ordered mesoporous carbon film as an effective solid-phase microextraction coating for determination of benzene series from aqueous media

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