Application of Solidago chilensis and laser improved the repair of burns in diabetic rats

Moreira, Juliana Aparecida Ramiro; Vasconcelos, Israel Costa; Fachi, José Luís; Theodoro, Viviane; Dalia, Rodrigo Augusto; Aro, Andréa Aparecida de; Pimentel, Edson Rosa; Gaspi, F.O.G.; Andrade, Thiago Antônio Moretti de; Amaral, Maria Esméria Corezola do; Esquisatto, Marcelo Augusto Marretto; Mendonça, Fernanda Aparecida Sampaio; Santos, Gláucia Maria Tech dos

doi:10.1016/j.bj.2020.05.014

Cited by 6 publications

(1 citation statement)

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“…To facilitate treatment, the healing of burn wounds is divided into the exudative stage, infection stage, repair stage, and rehabilitation stage artificially, this process is mutual superposition and mutual influence. 6 It is difficult to bandage the oral and maxillofacial region because of the uneven, especially the local accumulation of facial secretions caused by bandaging, and it is easy to complicate with wound infection. 7 As a result, maxillofacial burns are usually treated with exposure therapy, which traditionally involves applying silver sulfadiazine to burn wounds to promote the formation of dry scabs.…”

Section: Discussionmentioning

confidence: 99%

Clinical Study of Rh-bFGF Combined With Collagen Sponge in the Treatment of Maxillofacial Deep Ⅱ Degree Burn

Wang,

Yang,

Wang

et al. 2024

Journal of Craniofacial Surgery

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Objectives: To observe the clinical effect of recombinant human alkaline fibroblast growth factor (rh-bFGF) combined with collagen sponge in the treatment of maxillofacial deepⅡ degree burn. Methods: From January 2019 to January 2022, 96 patients with maxillofacial deep Ⅱ degree burns were randomly divided into a control group (N=48) and an observation group (N=48). The observation group was treated with rh-bFGF and collagen sponge after debridement, whereas the control group was treated with silver sulfadiazine ointment after debridement. The healing rate and healing time of the wounds were observed, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-10, epidermal growth factor (EGF), endothelial growth factor growth factor (VEGF), and metalloproteinase tissue inhibitor 1 (TIMP-1) were measured. Vancouver Scar Scale (VSS) was used to evaluate the local scar at 6 months after wound healing in both groups. Results: On the 10th, 14th, and 21st day of treatment, the wound healing rate in the observation group was higher than that in the control group (P<0.05), the wound healing time in the observation group was lower than that in the control group (P<0.05), and on the 14th day of treatment, the levels of TNF-α and IL-6 in the observation group were lower than those in the control group (P<0.05). The levels of IL-10 in the observation group were higher than those in the control group (P<0.05). The levels of EGF, VEGF, and TIMP-1 in the observation group were higher than those in the control group (P<0.05), and the scores of VSS in the observation group were lower than those in the control group (P<0.05). Conclusions: Rh-bFGF combined with collagen sponge can decrease the levels of TNF-α and IL-6 and increase the levels of IL-10, which can control the inflammation effectively, at the same time, it can increase the level of EGF, VEGF, and TIMP-1, promote wound healing, and reduce scar hyperplasia. The treatment protocol is simple, safe, effective, and suitable for clinical application.

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Section: Discussionmentioning

confidence: 99%