Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems

Lukova, Paolina; Katsarov, Plamen; Pilicheva, Bissera

doi:10.3390/polym15173615

Cited by 23 publications

(6 citation statements)

References 172 publications

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“…During oral administration, these microbeads penetrate the intestinal mucosa, potentially extending their residence time in the intestine [ 27 ]. A small particle size is essential for pulmonary delivery [ 28 ]. In this study, TBAH and TBPH were chosen as the solvents to create cellulose-based hydrogel microbeads.…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Cellulose/Silk/Fe3O4 Hydrogel Microbeads Designed for Biomedical Applications

Weon,

Na,

Han

et al. 2024

Gels

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In this study, cellulose/Fe3O4 hydrogel microbeads were prepared through the sol–gel transition of a solvent-in-oil emulsion using various cellulose-dissolving solvents and soybean oil without surfactants. Particularly, 40% tetrabutylammonium hydroxide (TBAH) and 40% tetrabutylphosphonium hydroxide (TBPH) dissolved cellulose at room temperature and effectively dispersed Fe3O4, forming cellulose/Fe3O4 microbeads with an average diameter of ~15 µm. Additionally, these solvents co-dissolved cellulose and silk, allowing for the manufacture of cellulose/silk/Fe3O4 hydrogel microbeads with altered surface characteristics. Owing to the negatively charged surface characteristics, the adsorption capacity of the cellulose/silk/Fe3O4 microbeads for the cationic dye crystal violet was >10 times higher than that of the cellulose/Fe3O4 microbeads. When prepared with TBAH, the initial adsorption rate of bovine serum albumin (BSA) on the cellulose/silk/Fe3O4 microbeads was 18.1 times higher than that on the cellulose/Fe3O4 microbeads. When preparing TBPH, the equilibrium adsorption capacity of the cellulose/silk/Fe3O4 microbeads for BSA (1.6 g/g) was 8.5 times higher than that of the cellulose/Fe3O4 microbeads. The pH-dependent BSA release from the cellulose/silk/Fe3O4 microbeads prepared with TBPH revealed 6.1-fold slower initial desorption rates and 5.2-fold lower desorption amounts at pH 2.2 than those at pH 7.4. Cytotoxicity tests on the cellulose and cellulose/silk composites regenerated with TBAH and TBPH yielded nontoxic results. Therefore, cellulose/silk/Fe3O4 microbeads are considered suitable pH-responsive supports for orally administered protein pharmaceuticals.

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Section: Resultsmentioning

confidence: 99%

pH-Responsive Cellulose/Silk/Fe3O4 Hydrogel Microbeads Designed for Biomedical Applications

Weon,

Na,

Han

et al. 2024

Gels

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“…This strategy can achieve the desired outcome, reducing biological toxicity [236][237][238]. Supramolecular interactions are promising for achieving site-specific drug or biomolecule release and addressing biological barriers [239][240][241][242][243][244][245]. The following section presents several drug delivery systems based on pillar[n]arene derivatives.…”

Section: Drug Delivery Systemmentioning

confidence: 99%

Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules

Li,

Jin,

Zhu

et al. 2023

Polymers

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Supramolecular chemistry enables the manipulation of functional components on a molecular scale, facilitating a “bottom-up” approach to govern the sizes and structures of supramolecular materials. Using dynamic non-covalent interactions, supramolecular polymers can create materials with reversible and degradable characteristics and the abilities to self-heal and respond to external stimuli. Pillar[n]arene represents a novel class of macrocyclic hosts, emerging after cyclodextrins, crown ethers, calixarenes, and cucurbiturils. Its significance lies in its distinctive structure, comparing an electron-rich cavity and two finely adjustable rims, which has sparked considerable interest. Furthermore, the straightforward synthesis, uncomplicated functionalization, and remarkable properties of pillar[n]arene based on supramolecular interactions make it an excellent candidate for material construction, particularly in generating interpenetrating supramolecular polymers. Polymers resulting from supramolecular interactions involving pillar[n]arene find potential in various applications, including fluorescence sensors, substance adsorption and separation, catalysis, light-harvesting systems, artificial nanochannels, and drug delivery. In this context, we provide an overview of these recent frontier research fields in the use of pillar[n]arene-based supramolecular polymers, which serves as a source of inspiration for the creation of innovative functional polymer materials derived from pillar[n]arene derivatives.

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“…The acidic conditions (pH 3.0-6.0) are optimal for stabilizing grapefruit extracts rich in flavonoids and ascorbic acid; the latter is particularly vulnerable to degradation at higher pH levels [22]. Excipients such as β-cyclodextrin and carboxymethylcellulose enhance the solubility and stability of these bioactive compounds under acidic conditions, playing pivotal roles in maintaining the integrity of the emulsion [10,23].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Encapsulation: Comparative Analysis of Spray-Drying and Freeze-Drying for Sustainable Recovery of Bioactive Compounds from Citrus x paradisi L. Peels

Stabrauskiene,

Pudziuvelyte,

Bernatoniene

2024

Pharmaceuticals

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Spray-drying and freeze-drying are indispensable techniques for microencapsulating biologically active compounds, crucial for enhancing their bioavailability and stability while protecting them from environmental degradation. This study evaluates the effectiveness of these methods in encapsulating Citrus x paradisi L. (grapefruit) peel extract, focusing on sustainable recovery from waste peels. Key objectives included identifying optimal wall materials and assessing each encapsulation technique’s impact on microencapsulation. The investigation highlighted that the choice of wall material composition significantly affects the microencapsulation’s efficiency and morphological characteristics. A wall material mixture of 17 g maltodextrin, 0.5 g carboxymethylcellulose, and 2.5 g β-cyclodextrin was optimal for spray drying. This combination resulted in a sample with a wettability time of 1170 (s), a high encapsulation efficiency of 91.41%, a solubility of 60.21%, and a low moisture content of 5.1 ± 0.255%. These properties indicate that spray-drying, particularly with this specific wall material composition, offers a durable structure and can be conducive to prolonged release. Conversely, varying the precise compositions used in the freeze-drying process yielded different results: quick wettability at 132.6 (s), a solubility profile of 61.58%, a moisture content of 5.07%, and a high encapsulation efficiency of 78.38%. The use of the lyophilization technique with this latter wall material formula resulted in a more porous structure, which may facilitate a more immediate release of encapsulated compounds and lower encapsulation efficiency.

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Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems

Cited by 23 publications

References 172 publications

pH-Responsive Cellulose/Silk/Fe3O4 Hydrogel Microbeads Designed for Biomedical Applications

pH-Responsive Cellulose/Silk/Fe3O4 Hydrogel Microbeads Designed for Biomedical Applications

Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules

Optimizing Encapsulation: Comparative Analysis of Spray-Drying and Freeze-Drying for Sustainable Recovery of Bioactive Compounds from Citrus x paradisi L. Peels

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