Application of sugar-containing biomass: one-step synthesis of 2-furylglyoxylic acid and its derivatives from a vitamin C precursor

Abstract

We developed a novel pathway for preparing the high-value pharmaceutical intermediate 2-furylglyoxylic acid (2FGA) from 2-keto-L-gulonic acid (2KGA), a bio-based sugar-acid monomer and precursor of vitamin C, via dehydration. 100...

Chemo-enzymatic cascades producing 2,5-furandicarboxylic acid precursors viad-gluconate “barbell oxidation” and dehydration

“…29 In our previous study, the dehydration of 2-keto- l -gulonic acid was proven to generate the furan derivative 2-furylglyoxylic acid instead of FDCA due to its sterically hindered configuration. 30 Although several new substrates for the preparation of FDCA were explored, their scarcity and difficult raw material synthesis represent challenges for obtaining suitable starting materials.…”

Chemical composition and bioactivity of hemp, reed canary grass and common reed grown on boreal marginal lands

“…24 Fresh or dried biomass displays benecial, value-added compounds such as cellulose, hemicellulose, carbohydrates, polyphenols, proteins, and lipids, with applications transiting various industries, including chemicals, pharmaceuticals, cosmetics, bre products, fuels, food packaging, and feed. [25][26][27][28] For instance, cellulose-derived sugars have emerged as critical feedstocks, facilitating a wide range of chemical reactions and enabling the substitution of petrochemicals with diverse chemicals beyond the scope of biofuels. 29 Notably, secondary metabolites found in such biomass are known for their multifaceted properties, encompassing antioxidant, antibacterial, antiviral, antihyperglycemic, antihypertensive and antiproliferative properties.…”