Application of superconducting quantum interference devices to nuclear magnetic resonance

Greenberg, Ya. S.

doi:10.1103/revmodphys.70.175

Cited by 191 publications

(69 citation statements)

References 146 publications

(238 reference statements)

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“…In this approach, the sample is pre-polarized by a relatively strong (up to 100 mT and higher) magnetic field prior to each imaging step. The second problem can be solved if highly sensitive SQUID (superconducting quantum interference device) sensors [31] are used to measure NMR signals [32][33][34][35]. SQUIDs with untuned input circuits are typically employed [16][17][18][19][20][21][22][23][24][25][26][27], because their response is independent of frequency.…”

Section: Introductionmentioning

confidence: 99%

Parallel MRI at microtesla fields

Zotev

Volegov

Matlashov

et al. 2008

Journal of Magnetic Resonance

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Parallel imaging techniques have been widely used in high-field magnetic resonance imaging (MRI). Multiple receiver coils have been shown to improve image quality and allow accelerated image acquisition. Magnetic resonance imaging at ultra-low fields (ULF MRI) is a new imaging approach that uses SQUID (superconducting quantum interference device) sensors to measure the spatially encoded precession of pre-polarized nuclear spin populations at microtesla-range measurement fields. In this work, parallel imaging at microtesla fields is systematically studied for the first time. A seven-channel SQUID system, designed for both ULF MRI and magnetoencephalography (MEG), is used to acquire 3D images of a human hand, as well as 2D images of a large water phantom. The imaging is performed at 46 microtesla measurement field with pre-polarization at 40 mT. It is shown how the use of seven channels increases imaging field of view and improves signal-to-noise ratio for the hand images. A simple procedure for approximate correction of concomitant gradient artifacts is described. Noise propagation is analyzed experimentally, and the main source of correlated noise is identified. Accelerated imaging based on one-dimensional undersampling and 1D SENSE (sensitivity encoding) image reconstruction is studied in the case of the 2D phantom. Actual 3-fold imaging acceleration in comparison to single-average fully encoded Fourier imaging is demonstrated. These results show that parallel imaging methods are efficient in ULF MRI, and that imaging performance of SQUID-based instruments improves substantially as the number of channels is increased.

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Section: Introductionmentioning

confidence: 99%

Parallel MRI at microtesla fields

Zotev

Volegov

Matlashov

et al. 2008

Journal of Magnetic Resonance

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“…¿ÕË ÒÓÇAEÔÍÂÊÂÐËâ ÃÎËÊÍË Í ÑÔÖÜÇÔÕÄÎÇÐËá. £ ÔÄâÊË Ô àÕËÏ ÑÔÕÂÐÑÄËÏÔâ ÐÂ ÔÓÂÄÐÇÐËË ÚÖÄÔÕÄË-ÕÇÎßÐÑÔÕË ÂÒÒÂÓÂÕÖÓÞ, ÑÔÐÑÄÂÐÐÑÌ ÐÂ ÕÓÈØ ÐÂËÃÑÎÇÇ ÖÐËÄÇÓÔÂÎßÐÞØ ÏÇÕÑAEÂØ ÓÇÅËÔÕÓÂÙËË ÏÂÅÐËÕÐÑÅÑ ÓÇÊÑ-ÐÂÐÔÂ: ËÐAEÖÍÙËÑÐÐÑÏ [11,14], ³¬£ª¥ [117] Ë ®²³® [194].°ÃÜÇÇ ÄÞÓÂÉÇÐËÇ AEÎâ ÑÕÐÑÛÇÐËâ ÔËÅÐÂÎÂ Í ÛÖÏÖ AEÎâ N s ÔÒËÐÑÄ I Ô ÅËÓÑÏÂÅÐËÕÐÞÏ ÑÕÐÑÛÇÐËÇÏ g Ä ÒÑÎÇ H Ä àÕËØ ÏÇÕÑAEÂØ ËÏÇÇÕ ÄËAE [197].…”

Section: ±óçAeþôõñóëâ ñõíóþõëçunclassified

Magnetic resonance: discovery, investigation and application

Kessenikh¹

2009

Usp. Fiz. Nauk

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“…∆f in a pulsed NMR experiment is inversely proportional to T 2 and has already been included in Eqn. (7) and (10). m 0 = M 0 V d is the net magnetic moment of the spins inside the coil volume, which is transported without loss from the encoding to the detection location in an ideal remote experiment.…”

mentioning

confidence: 99%

“…For example, DC magnetometers such as superconducting quantum interference devices (SQUIDs) [10] or optical magnetometers [11] may be preferred at low fields. Alternatively, spin-exchange optical detection could serve as a technique that is specific to measure the polarization of noble gas sensor media.…”

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confidence: 99%

Sensitivity quantification of remote detection NMR and MRI

Granwehr

Seeley

2006

Journal of Magnetic Resonance

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A sensitivity analysis of the remote detection NMR technique is presented. With remote detection, information about a sample is encoded onto a mobile sensor fluid, which facilitates a spatial separation of encoding and detection of spin magnetization. This approach can be interpreted as a two-dimensional NMR experiment, therefore the same general formalism can be used for a sensitivity analysis. Even though remote detection is a point-by-point experiment, the sensitivity does not scale unfavorably with the number of detected points compared to transient detection. It is proportional to the relative sensitivity between the remote detector and the circuit that is used for encoding. The influence of the different signal decay times is analyzed, and the distinction between spectroscopy and imaging experiments is made.Key words: NMR, MRI, Remote detection, Sensitivity, Indirect detection, Flow NMR remote detection, a novel technique to spatially and temporally separate encoding and detection of nuclear spin magnetization, has the potential to enhance the sensitivity of NMR spectroscopy and imaging experiments. It employs a flowing sensor medium that samples a stationary analyte of interest, which can be a liquid, a surface, a porous medium, or void space [1,2]. In these experiments the sensor medium, thus far hyperpolarized 129 Xe [3], is first introduced to a sample of interest, is encoded with information regarding that sample, and is then transferred to a different location for sensitive detection. This separation of the encoding and detection steps allows optimizing them independently. The encoding region may be configured in the most convenient way to accommodate the sample, while different conditions optimized for sensitivity are used in the detection region. This communication aims to provide a more quantitative discussion of the sensitivity achievable with this technique.The longitudinal magnetization of the sensor medium is the property that is altered by the encoding step. An arbitrary pulse sequence can be used that is able to transfer the desired information about the stationary analyte onto longitudinal magnetization of the sensor medium.

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Application of superconducting quantum interference devices to nuclear magnetic resonance

Cited by 191 publications

References 146 publications

Parallel MRI at microtesla fields

Parallel MRI at microtesla fields

Magnetic resonance: discovery, investigation and application

Sensitivity quantification of remote detection NMR and MRI

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