Application of supercritical technology in the production of dietary supplement based on plant extracts

Pires, Flávia; Silva, Ana Paula de Souza e; Silva, Ivonete Quaresma da; Oliveira, Joicy Corrêa de; Menezes, Eduardo Gama Ortiz; Costa, Wanessa Almeida da; Carvalho, Raul Nunes de

doi:10.1016/b978-0-12-821885-3.00006-2

Cited by 2 publications

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“…Many studies have approached the use of supercritical CO 2 to obtain nonpolar plant extracts. Among the main compounds present in such extracts, unsaturated fatty acids and carotenoids stand out due to their beneficial health effects [14][15][16][17]. In addition, other studies have addressed their applications due to the characteristics of their medium and long-chain triglycerides [18][19][20][21].…”

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confidence: 99%

Bioactive Compounds and Evaluation of Antioxidant, Cytotoxic and Cytoprotective Effects of Murici Pulp Extracts (Byrsonima crassifolia) Obtained by Supercritical Extraction in HepG2 Cells Treated with H2O2

Pires

Oliveira

Menezes

et al. 2021

Foods

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The use of clean technologies in the development of bioactive plant extracts has been encouraged, but it is necessary to verify the cytotoxicity and cytoprotection for food and pharmaceutical applications. Therefore, the objective of this work was to obtain the experimental data of the supercritical sequential extraction of murici pulp, to determine the main bioactive compounds obtained and to evaluate the possible cytotoxicity and cytoprotection of the extracts in models of HepG2 cells treated with H2O2. The murici pulp was subjected to sequential extraction with supercritical CO2 and CO2+ethanol, at 343.15 K, and 22, 32, and 49 MPa. Higher extraction yields were obtained at 49 MPa. The oil presented lutein (224.77 µg/g), oleic, palmitic, and linoleic, as the main fatty acids, and POLi (17.63%), POO (15.84%), PPO (13.63%), and LiOO (10.26%), as the main triglycerides. The ethanolic extract presented lutein (242.16 µg/g), phenolic compounds (20.63 mg GAE/g), and flavonoids (0.65 mg QE/g). The ethanolic extract showed greater antioxidant activity (122.61 and 17.14 µmol TE/g) than oil (43.48 and 6.04 µmol TE/g). Both extracts did not show cytotoxicity and only murici oil showed a cytoprotective effect. Despite this, the results qualify both extracts for food/pharmaceutical applications.

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