A study of air quality was performed using a compact, aircraft aerosol lidar designed in the Science Directorate at NASA Langley Research Center and Moderate Resolution Imaging Spectroradiometer (MODIS) aerosol optical depth (AOD) retrievals. Five flights of lidar measurements conducted in the Hampton-Norfolk-Virginia Beach, Virginia, region showed complex regional aerosol distributions. Comparisons with MODIS AOD at 10 km 3 10 km and 5 km 3 5 km resolutions show good agreement, with correlation R 2 values of 0.82 and 0.88, respectively. Linear regressions of particulate matter with a diameter of less than 2.5 mm (PM2.5) and AOD within the ranges of 5-40 mg m 23 and 0.05-0.7, respectively, result in R 2 values of ;0.64 and ;0.82 for MODIS and the Compact Aerosol Lidar, respectively. The linear regressions reflect approximately 51 mg m 23 to 1 AOD. These relationships are in agreement with previous findings for air pollution aerosols in the eastern United States and in northern Italy. However, large vertical variation is seen case by case, with planetary boundary layer heights ranging between 0.7 and 2 km and uncertainties ranging between 0.1 and 0.4 km. The results of the case studies suggest that AOD can be used as an indicator of surface measurements of PM2.5 but with larger uncertainties associated with small aerosol loading (AOD , 0.3).