Background: The senile lung undergoes physiologic changes that are well known but have not been investigated with computed tomographic (CT) texture analysis. The thin-section pulmonary computed tomographic (CT) microstructure features change in asymptomatic elderly individuals were not explored.Methods: We retrospectively selected 259 subjects under-going chest computed tomography (CT) between April 2018 and June 2019, as group A(consist of group1 and group2), without a history of smoking within the past 5 years, respiratory symptoms or any known chronic pulmonary disease. There were 118 patients in group 1(age ≥ 60 years-elderly) and 141 patients in group 2 (age≤50 years-young). Furthermore, 273 patients with pulmonary function tests(PFTs) were included as group B, which divided into two cohorts, chronic obstructive pulmonary disease (COPD) (n=83) and non-COPD (healthy smoker [HS], n=90; healthy non-smoker [HNS], n=100) cohort. The radiomic features were extracted and selected from group A, trialed in group B, using the LASSO algorithm.Results: A total of 233 features were significant in group A. Among these features, 17 features exhibited distinct differences between COPD and non-COPD patients, 18 features exhibit distinct differences between HSs and HNSs. Meanwhile, five features were shared in group B. A negative correlation was determined between carbon monoxide diffusing capacity(DLCO) and the two features: ShortRunLowGreyLevelEmphasis_AllDirection_offset9_SD (ρ = -0.70) and LowGreyLevelRunEmphasis_AllDirection_offset2_SD (ρ = -0.63). Similarly, a positive correlation was found between FEV1/FVC and HighGreyLevelRunEmphasis_AllDirection_offset8_SD (ρ = 0.74).Conclusion: Radiomic features, which associated with the ages and significant in COPD patients and smokers, maybe reveal the microstructure changes of the aging lungs.