Application of the 2011 international consensus cancer cachexia classification in routine oncology dietetic practice: An observational study

Aktaş, Aynur; Lorton, Cliona; Griffin, Oonagh; Higgins, K.; Roulston, F.; Stewart, G.; Corkery, Niamh; Barnes, Elizabeth; Walsh, Declan

doi:10.1002/ncp.10915

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Cachexia is a wasting syndrome associated with chronic illnesses, including cancer, and characterized by weight loss and skeletal muscle wasting [152]. The consensus definition of cancer cachexia [153] boosted the recognition of its clinical relevance [154]. The prevalence of cachexia is very high (50-80%) in advanced malignant cancer [155].…”

Section: Major Differences In Clinical and Pre-clinical Phenotypesmentioning

confidence: 99%

Sex Differences in Inflammation and Muscle Wasting in Aging and Disease

Peruta

Lozanoska-Ochser

Renzini

et al. 2023

IJMS

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Only in recent years, thanks to a precision medicine-based approach, have treatments tailored to the sex of each patient emerged in clinical trials. In this regard, both striated muscle tissues present significant differences between the two sexes, which may have important consequences for diagnosis and therapy in aging and chronic illness. In fact, preservation of muscle mass in disease conditions correlates with survival; however, sex should be considered when protocols for the maintenance of muscle mass are designed. One obvious difference is that men have more muscle than women. Moreover, the two sexes differ in inflammation parameters, particularly in response to infection and disease. Therefore, unsurprisingly, men and women respond differently to therapies. In this review, we present an up-to-date overview on what is known about sex differences in skeletal muscle physiology and disfunction, such as disuse atrophy, age-related sarcopenia, and cachexia. In addition, we summarize sex differences in inflammation which may underly the aforementioned conditions because pro-inflammatory cytokines deeply affect muscle homeostasis. The comparison of these three conditions and their sex-related bases is interesting because different forms of muscle atrophy share common mechanisms; for instance, those responsible for protein dismantling are similar although differing in terms of kinetics, severity, and regulatory mechanisms. In pre-clinical research, exploring sexual dimorphism in disease conditions could highlight new efficacious treatments or recommend implementation of an existing one. Any protective factors discovered in one sex could be exploited to achieve lower morbidity, reduce the severity of the disease, or avoid mortality in the opposite sex. Thus, the understanding of sex-dependent responses to different forms of muscle atrophy and inflammation is of pivotal importance to design innovative, tailored, and efficient interventions.

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Section: Major Differences In Clinical and Pre-clinical Phenotypesmentioning

confidence: 99%

Sex Differences in Inflammation and Muscle Wasting in Aging and Disease

Peruta

Lozanoska-Ochser

Renzini

et al. 2023

IJMS

View full text Add to dashboard Cite

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Clinical characteristics of gastrointestinal stromal tumors with hypoglycemia

Chida,

Kawasaki,

Kuramoto

et al. 2024

Oncol Lett

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The development of tyrosine-kinase inhibitors has improved survival rates for patients with gastrointestinal stromal tumors (GISTs). Despite the progress, not all the patients can universally receive the benefit from treatment due to the individual underlying conditions in a real-world setting. The present study focused on the well-known but understudied condition of GIST with hypoglycemia. Hypoglycemia in GIST is characterized by hypoglycemic symptoms such as dizziness, sweating and confusion. It is caused by several factors such as multiple liver metastases, drug adverse effects, postoperative complications and paraneoplastic syndrome [non-islet cell tumor hypoglycemia (NICTH)]. Comprehensive analysis of this condition has been hindered due to its rarity, and has been mostly limited to case reports. In the present study, a single-institution retrospective analysis of GIST with hypoglycemia was conducted to investigate its prevalence and prognosis, and the cause of this condition. The present study identified that the prevalence of hypoglycemic episodes of GIST was 4.1% in all patients with GIST, and recurrent hypoglycemic cases had a poor prognosis. The present study identified 1 case with recurrent hypoglycemia due to NICTH. Since NICTH is a rare hypoglycemic cause and requires further evaluation, an autopsy and genetic sequencing were performed using the available clinical materials. Through this histological and genetic investigation, the histological diversity of NICTH-GIST was revealed and insulin-like growth factor II (IGF-II) amplification was identified. Furthermore, a chronological analysis was performed using multiple resected archived samples from the same case, and revealed that diffuse IGF-II expression may have occurred in the early phase of tumor development. The present study catalogued the characteristics of GIST with hypoglycemia with a focus on NICTH-GIST.

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Application of the 2011 international consensus cancer cachexia classification in routine oncology dietetic practice: An observational study

Cited by 2 publications

References 33 publications

Sex Differences in Inflammation and Muscle Wasting in Aging and Disease

Sex Differences in Inflammation and Muscle Wasting in Aging and Disease

Clinical characteristics of gastrointestinal stromal tumors with hypoglycemia

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