Abstract:In this work, we present a dynamic behavior of the avian-human in uenza epidemic model by using ecient computational algorithm, namely the multistage differential transform method(MsDTM). The MsDTM is used here as an algorithm for approximating the solutions of the avian-human in uenza epidemic model in a sequence of time intervals. In order to show the e ciency of the method, the obtained numerical results are compared with the fourth-order Runge-Kutta method (RK4M) and di erential transform method(DTM) solutions. It is shown that the MsDTM has the advantage of giving an analytical form of the solution within each time interval which is not possible in purely numerical techniques like RK4M.