Application of the GC-HRMS based method for monitoring of short- and medium-chain chlorinated paraffins in vegetable oils and fish

Tomasko, Jakub; Stupák, Michal; Hajšlová, Jana; Pulkrabová, Jana

doi:10.1016/j.foodchem.2021.129640

“…The instrumental analysis of CPs in food and biological samples (usually at trace levels) (9,10) is a demanding task. In recent years, several gas chromatography (GC) or liquid chromatography (LC)-based methods have been published (9)(10)(11)(12). Nevertheless, CPs cannot be completely separated to individual compounds, which has led (together with the lack of well-characterized standard mixtures) to the need for unconventional quantification approaches (13)(14)(15).…”

Section: Scanmentioning

confidence: 99%

“…The matrix effects were evaluated by comparing matrix standards (prepared in duplicate) with solvent standards at a level of 0.6 µg/g lw. The equation used for the evaluation was described elsewhere (12). The sample preparation was performed as described in the "Methods and Materials" section.…”

Section: Evaluation Of Matrix Effectsmentioning

confidence: 99%

An Overview of the Untargeted Analysis Using LC–MS (QTOF): Experimental Process and Design Considerations

Liden,

Wang,

Schug

2023

LCGC N. Am.

0

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Untargeted analysis using liquid chromatography with tandem mass spectrometry (LC–MS/MS) chemical profiling has become a valuable tool for providing insight into the variations found in a sample set. However, the large data sets often generated, frequently yielding upwards of 20,000 features or more, can be overwhelming. Key elements in creating an experimental design are one of the most pivotal aspects of verifying statistical variance in a sample set. Therefore, care should be taken when an experimental design is developed and when statistical tools are used to perform data reduction and processing.

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“…The instrumental analysis of CPs in food and biological samples (usually at trace levels) (9,10) is a demanding task. In recent years, several gas chromatography (GC) or liquid chromatography (LC)-based methods have been published (9)(10)(11)(12). Nevertheless, CPs cannot be completely separated to individual compounds, which has led (together with the lack of well-characterized standard mixtures) to the need for unconventional quantification approaches (13)(14)(15).…”

Section: Scanmentioning

confidence: 99%

“…The matrix effects were evaluated by comparing matrix standards (prepared in duplicate) with solvent standards at a level of 0.6 µg/g lw. The equation used for the evaluation was described elsewhere (12). The sample preparation was performed as described in the "Methods and Materials" section.…”

Section: Evaluation Of Matrix Effectsmentioning

confidence: 99%

Low-Resolution or High-Resolution MS for Clinical and Forensic Toxicology: Some Considerations from Two Real Cases

Zarrouk,

El Balkhi,

Saint-Marcoux

2023

LCGC N. Am.

2

0

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“…The instrumental analysis of CPs in food and biological samples (usually at trace levels) (9,10) is a demanding task. In recent years, several gas chromatography (GC) or liquid chromatography (LC)-based methods have been published (9)(10)(11)(12). Nevertheless, CPs cannot be completely separated to individual compounds, which has led (together with the lack of well-characterized standard mixtures) to the need for unconventional quantification approaches (13)(14)(15).…”

Section: Scanmentioning

confidence: 99%

Application of Liquid- and Supercritical Fluid Chromatography Coupled with High-Resolution Mass Spectrometry for the Analysis of Short-, Medium-, and Long-Chain Chlorinated Paraffins in Dietary Supplements

Tomasko,

Maxa,

Navratilova

et al. 2023

LCGC N. Am.

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Chlorinated paraffins (CPs) are an emerging and ubiquitous group of environmental pollutants associated with adverse effects on human health, including endocrine disruption and possible carcinogenicity. In this study, supercritical fluid chromatography (SFC) and ultrahigh-performance liquid chromatography (UHPLC)—both coupled with high-resolution mass spectrometry (HRMS)—methods for the analysis of short-, medium-, and long-chain CPs in fish oil-based dietary supplements were developed and validated at concentration levels of 0.6 and 3.0 μg/g lipid weight (lw). The recoveries were in the range of 80–96% and repeatabilities, expressed as relative standard deviations, were <19%. The limits of detection for the UHPLC–HRMS method (from 0.03 to 0.05 μg/g lw) were 5 to 10 times lower than those obtained by SFC–HRMS (from 0.13 to 0.50 μg/lw).

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Application of the GC-HRMS based method for monitoring of short- and medium-chain chlorinated paraffins in vegetable oils and fish

Cited by 12 publications

References 29 publications

An Overview of the Untargeted Analysis Using LC–MS (QTOF): Experimental Process and Design Considerations

An Overview of the Untargeted Analysis Using LC–MS (QTOF): Experimental Process and Design Considerations

Low-Resolution or High-Resolution MS for Clinical and Forensic Toxicology: Some Considerations from Two Real Cases

Application of Liquid- and Supercritical Fluid Chromatography Coupled with High-Resolution Mass Spectrometry for the Analysis of Short-, Medium-, and Long-Chain Chlorinated Paraffins in Dietary Supplements

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