Application of the immune complex for immune protection against viral disease

Pokrić, Biserka; Sladić, Dušan; Juroš, S.; Čajavec, Stanislav

doi:10.1016/0264-410x(93)90312-l

Cited by 21 publications

(12 citation statements)

References 28 publications

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“…Consistent with our findings of immunomodulatory activity associated with an anti-S. mutans MAb, several investigators have suggested that an exogenously administered antibody may act as a therapeutic agent by redirecting the host response against an infectious agent rather than playing a purely passive role (5,27,55,58,59,72,86). Bouige et al showed that parenteral immunomodulation by MAb could occur with different types of antigens, including a human soluble protein, specifically sIgA, a bacterial polysaccharide from E. coli K1, and an envelope protein from the hepatitis B virus (5,6).…”

Section: Discussionsupporting

confidence: 91%

“…Bouige et al showed that parenteral immunomodulation by MAb could occur with different types of antigens, including a human soluble protein, specifically sIgA, a bacterial polysaccharide from E. coli K1, and an envelope protein from the hepatitis B virus (5,6). Generation of antibodies recognizing novel epitopes by immunization with immune complexes or sequential administration of specific antibody followed by antigen has been achieved against feline CD4 (81) and Actinobacillus pleuropneumoniae (70) and has been used to elicit protective immunity against Newcastle disease virus in chickens (55).…”

Section: Discussionmentioning

confidence: 99%

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Monoclonal Antibody-Mediated Modulation of the Humoral Immune Response against Mucosally AppliedStreptococcus mutans

et al. 2000

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Systemic immunization with antigen coupled to monoclonal antibody (MAb) has been used by several investigators to increase the number of MAb-producing hybridomas against an antigen and to elicit antibodies specific for poorly immunogenic epitopes. This strategy has implications for vaccine design in that protective immunity is not necessarily directed at immunodominant epitopes of pathogens and may be improved by deliberately shifting the immune response toward subdominant epitopes. To our knowledge, no studies to date have addressed the potential for immunomodulatory activity mediated by MAbs bound to mucosally applied antigen. To test whether administration of an exogenous MAb directed against a streptococcal surface protein could influence the humoral immune response, BALB/c mice were immunized orally by gastric intubation or intranasally with Streptococcus mutans alone or S. mutans complexed with a MAb directed against the major surface protein P1. Significant changes in the subclass distribution, as well as the specificity, of anti-P1 serum immunoglobulin G antibodies were demonstrated in groups of mice which received S. mutans coated with the anti-P1 MAb versus those which received S. mutans alone. Alterations in the humoral immune response were dependent on the amount of anti-P1 MAb used to coat the bacteria. In addition, differences in the anti-P1 immune responses were observed between groups of mice immunized via oral versus intranasal routes. In summary, an exogenous MAb complexed with a streptococcal antigen prior to mucosal immunization can influence the immunoglobulin isotype and specificity of the host humoral immune response against the antigen.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Monoclonal Antibody-Mediated Modulation of the Humoral Immune Response against Mucosally AppliedStreptococcus mutans

et al. 2000

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“…However, the benefit of utilizing antibody in combination with antigen to achieve a desirable immune response is far less appreciated and is the focus of this minireview. There is increasing recognition that exogenously administered antibody may exert a therapeutic effect by redirecting the host response rather than by playing a purely passive role (16,18,26,45,53,55,56,84,90,93,100,114,129). Both polyclonal and monoclonal reagents, administered either alone or in combination with antigen, have been used to up-regulate beneficial or protective immune responses against infectious agents and malignant tumors as well as to down-regulate deleterious responses associated with inflammation, autoimmunity, and hypersensitivity (8,55,57,58,84,102,110).…”

mentioning

confidence: 99%

Antibody-Mediated Immunomodulation: a Strategy To Improve Host Responses against Microbial Antigens

Brady

2005

Infect Immun

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“…Systemic and mucosal immunization with an antigen bound by a monoclonal antibody (MAb) has been used to elicit humoral immunity against poorly immunogenic epitopes (7,39,45,47,48,62,66). Immunomodulation by antibodies is a strategy that can be used to deliberately shift reactivity away from immunodominant but nonprotective epitopes toward subdominant but more protective epitopes (1,6,25,35,37,69).…”

mentioning

confidence: 99%

Characterization of theStreptococcus mutansP1 Epitope Recognized by Immunomodulatory Monoclonal Antibody 6-11A

et al. 2004

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Monoclonal antibody (MAb) 6-11A directed against Streptococcus mutans surface adhesin P1 was shown previously to influence the mucosal immunogenicity of this organism in BALB/c mice. The specificity of anti-P1 serum immunoglobulin G (IgG) and secretory IgA antibodies and the subclass distribution of anti-P1 serum IgG antibodies were altered, and the ability of elicited serum antibodies to inhibit S. mutans adherence in vitro was in certain cases increased. MAb 6-11A is known to recognize an epitope dependent on the presence of the proline-rich region of the protein, although it does not bind directly to the isolated P-region domain. In this report, we show that MAb 6-11A recognizes a complex discontinuous epitope that requires the simultaneous presence of the alanine-rich repeat domain (A-region) and the P-region. Formation of the core epitope requires the interaction of these segments of P1. Residues amino terminal to the A-region also contributed to recognition by MAb 6-11A but were not essential for binding. Characterization of the MAb 6-11A epitope will enable insight into potential mechanisms of immunomodulation and broaden our understanding of the tertiary structure of P1.

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Application of the immune complex for immune protection against viral disease

Cited by 21 publications

References 28 publications

Monoclonal Antibody-Mediated Modulation of the Humoral Immune Response against Mucosally AppliedStreptococcus mutans

Monoclonal Antibody-Mediated Modulation of the Humoral Immune Response against Mucosally AppliedStreptococcus mutans

Antibody-Mediated Immunomodulation: a Strategy To Improve Host Responses against Microbial Antigens

Characterization of theStreptococcus mutansP1 Epitope Recognized by Immunomodulatory Monoclonal Antibody 6-11A

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