Application of the immune-correcting therapy in complex treatment of surgical forms of erysipelas

Abstract

Objective. To investigate the efficacy of immunomodulating and immunostimulating therapy in complex treatment of patients, suffering surgical forms of erysipelas.Materials and methods. Retrospectively and prospectively there were analyzed 284 patients’ hospital charts, who were treated stationary in Centre of Purulent-Septic Surgery of Zaporizhzhya Municipal Hospital №3 in 2016 - 2021 yrs.
 Results. In patients, suffering erythematous form of erysipelas, disorders in cellular and humoral chains of immunity were not revealed. The immune disorders formula in bullous form was following: CD3 + 1, CD4 + 1, CD8-1, CD16-2, CD22-1, what witnessed about misbalance of the immune system Degree I, of possibly compensatory character; in a phlegmonous one - CD3 + 1, CD4-1, CD8-1, CD16-2, CD22-1, witnessing actuality of the immune disorders of Degree І, while in the necrotic one - CD3-2, CD4-2, CD8-1, CD16-2, CD22-1, trusting presence of the immune disorders of Degree ІІI.
 Conclusion. Administration of erbisol-extra and laferon for destructive forms of erysipelas is pathogenetically substantiated and may be applied in complex treatment of the disease.

Reasons for unsatisfactory results of treatment of destructive forms of erysipelas

“…Все частіше спостерігається зміна клінічної симптоматики та перебігу захворювання з розвитком тяжких ускладнень та сепсису. Летальність серед некротичної форми хвороби коливається в межах від 5,8 до 81% та, як правило, зумовлюється розвитком сепсису [3,4,5,7]. У цьому контексті важливо своєчасно розпізнати розвиток сепсису, оцінити загальний стан хворого та визначити подальшу стратегію лікування.…”