2021
DOI: 10.1002/pca.3041
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Application of the metabolomics approach to the discovery of active compounds from Brazilian trees against resistant human melanoma cells

Abstract: Introduction:The chemical diversity of plants plays an essential role in the development of new drugs. However, new bioactive compound identification and isolation are challenging due to the complexity and time-consuming nature of the traditional process. Recently, alternative strategies have become popular, such as the statistical approach to correlate compounds with biological activities, overcoming bottlenecks in bioactive natural product research.Objective: We aimed to determine bioactive compounds against… Show more

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Cited by 3 publications
(3 citation statements)
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“…Terpenoids are a diverse class of natural products containing approximately 40,000 known compounds, many of which possess favorable activities and are widely used in various fields such as medicine, food, and cosmetics (Hu et al 2017 ; Bohlmann and Keeling 2008 ). However, traditional methods of plant extraction are time-consuming, labor-intensive, and limited by plant growth (Lu et al 2012 ; Sousa et al 2005 ; Kato et al 2021 ). In recent years, with the rapid development of synthetic biology, efficient production of high-value terpene products using microbial cell factories has attracted increasing attention.…”
Section: Discussionmentioning
confidence: 99%
“…Terpenoids are a diverse class of natural products containing approximately 40,000 known compounds, many of which possess favorable activities and are widely used in various fields such as medicine, food, and cosmetics (Hu et al 2017 ; Bohlmann and Keeling 2008 ). However, traditional methods of plant extraction are time-consuming, labor-intensive, and limited by plant growth (Lu et al 2012 ; Sousa et al 2005 ; Kato et al 2021 ). In recent years, with the rapid development of synthetic biology, efficient production of high-value terpene products using microbial cell factories has attracted increasing attention.…”
Section: Discussionmentioning
confidence: 99%
“…Although chemotherapies are important tools for the treatment of different types of cancer, many of the currently used drugs have low selectivity, different levels of systemic toxicity, and cellular resistance to chemotherapeutic agents [ 10 , 11 ]. Thus, natural molecules arising from plants have played a significant role in the development of new chemotherapeutic agents by having a wide structural variety with antitumor potential [ 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…A enorme maioria dos estudos fitoquímicos em Copaifera relatam seus sesquiterpenos e diterpenos, pouco sendo publicado sobre os triterpenos. Dos estudos com a espécie já foram detectados, na casca, os triterpenos ácido betulínico (também detectado no presente estudo), lupeol(Veiga Jr & Pinto 2006) e acetato de lupeíla(Salatino et al 2020) Kato et al (2021). obtiveram um triterpeno do extrato DCM da folha com fórmula C30H46O3, porém esse não pôde…”
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