Application of the method of electro-acoustical analysis for the detection of bacteriophages in a liquid phase

Guliy, О. I.; Зайцев, Б. Д.; Kuznetsova, I. E.; Shikhabudinov, A. M.; Balko, Alex; Teplykh, А. Е.; Староверов, С. А.; Дыкман, Л. А.; Makarikhina, S. S.; Игнатов, О. В.

doi:10.1134/s0006350916010097

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…A promising direction for the analysis of viruses is the use of acoustic biosensors. Previously, the possibility for viruses’ detection was shown on the example of bacteriophages using an acoustic sensor and microbial cells [ 21 ], and antibodies [ 22 ] and phage mini-antibodies [ 23 ] were used as a selective agent. For viruses’ detection, the most preferred sensors are those that allow multiple measurements and are easily cleaned of the used sample after measurements without losing the sensor’s sensitivity to the analyzed reaction.…”

Section: Introductionmentioning

confidence: 99%

Acoustical Slot Mode Sensor for the Rapid Coronaviruses Detection

Guliy

Зайцев

Teplykh

et al. 2021

Sensors

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A method for the rapid detection of coronaviruses is presented on the example of the transmissible gastroenteritis virus (TGEV) directly in aqueous solutions with different conductivity. An acoustic sensor based on a slot wave in an acoustic delay line was used for the research. The addition of anti-TGEV antibodies (Abs) diluted in an aqueous solution led to a change in the depth and frequency of resonant peaks on the frequency dependence of the insertion loss of the sensor. The difference in the output parameters of the sensor before and after the biological interaction of the TGE virus in solutions with the specific antibodies allows drawing a conclusion about the presence/absence of the studied viruses in the analyzed solution. The possibility for virus detection in aqueous solutions with the conductivity of 1.9–900 μs/cm, as well as in the presence of the foreign viral particles, has been demonstrated. The analysis time did not exceed 10 min.

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Section: Introductionmentioning

confidence: 99%