Establishing the evidence base of interventions taking place in areas such as psychology and special education is one of the research aims of single-case designs in conjunction with the aim of improving the well-being of participants in the studies. The scientific criteria for solid evidence focus on the internal and external validity of the studies, and for both types of validity, replicating studies and integrating the results of these replications (i.e., meta-analyzing) is crucial. In the present study we deal with one of the aspects of meta-analysis, namely the weighting strategy used when computing an average effect size across studies. Several weighting strategies suggested for single-case designs are discussed and compared in the context of both simulated and real-life data. The results indicated that there are no major differences between the strategies and, thus we consider that it is important to choose weights with a sound statistical and methodological basis, while scientific parsimony is another relevant criterion. More empirical research and conceptual discussion are warranted regarding the optimal weighting strategy in single-case designs, alongside investigation of the optimal effect size measure in these types of design.Key words: single-case designs; meta-analysis; weight; effect size 3 The evidence-based movement has now been salient for several years in a variety of disciplines including psychology (APA Presidential Task Force on Evidence-Based Practice, 2006), medicine (Sackett, Rosenberg, Gray, Hayness, & Richardson, 1996), and special education . In this context, single-case designs ( Sidman, 1960) and, apart from using random assignment of conditions to measurement times, it is also favored by replication of the behavioral change contiguous with the change in conditions (Kratochwill et al., 2013;Wolery, 2013). On the other hand, replication is also related to generalization (Sidman, 1960), which benefits from research synthesis and metaanalysis. In that sense, the evidence-based movement has also paid attention to the metaanalytical integration of replications or studies on the same topic (Beretvas & Chung, 2008b;Jenson, Clark, Kircher, & Kristjansson, 2007). The quantitative integration is deemed especially useful when moderator variables are included in the meta-analyses (Burns, 2012;Wolery, 2013).Finally, it has been stressed that meta-analysis and the assessment of internal and external 1 We chose the term single-case designs (SCD) in order to be consistent with the labeling used in the articles recently published in this journal by, for instance, Baek and Ferron (2013) ). The present study represents an effort to discuss and obtain evidence regarding the metaanalysis of single-case studies; its focus is on weighting strategies rather than on the effect size measures that summarize the results. In that sense, it should be stressed that we do not advocate here for or against specific procedures for SCD data analysis. We consider that, while the debate on the optimal analytical...