Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now

Simeon, Michael; Dangwal, Seema; Sachinidis, Agapios; Doss, Michael Xavier

doi:10.3390/cells10113112

Cited by 5 publications

(1 citation statement)

References 128 publications

(103 reference statements)

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“…Patient-derived iPSCs have been already successfully applied to the research into cardiovascular diseases [ 47 ]. There are several examples of generation and application of patients’ iPSC-derived vascular cell types for modeling of cardiovascular diseases including cardiomyocytes (e.g.…”

Section: Current and Potential Applications Of Human Ipscs In Functio...mentioning

confidence: 99%

Functional genomics in stroke: current and future applications of iPSCs and gene editing to dissect the function of risk variants

Granata

2023

BMC Cardiovasc Disord

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Stroke is an important disease with unmet clinical need. To uncover novel paths for treatment, it is of critical importance to develop relevant laboratory models that may help to shed light on the pathophysiological mechanisms of stroke. Induced pluripotent stem cells (iPSCs) technology has enormous potential to advance our knowledge into stroke by creating novel human models for research and therapeutic testing. iPSCs models generated from patients with specific stroke types and specific genetic predisposition in combination with other state of art technologies including genome editing, multi-omics, 3D system, libraries screening, offer the opportunity to investigate disease-related pathways and identify potential novel therapeutic targets that can then be tested in these models. Thus, iPSCs offer an unprecedented opportunity to make rapid progress in the field of stroke and vascular dementia research leading to clinical translation. This review paper summarizes some of the key areas in which patient-derived iPSCs technology has been applied to disease modelling and discusses the ongoing challenges and the future directions for the application of this technology in the field of stroke research.

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Section: Current and Potential Applications Of Human Ipscs In Functio...mentioning

confidence: 99%

Functional genomics in stroke: current and future applications of iPSCs and gene editing to dissect the function of risk variants

Granata

2023

BMC Cardiovasc Disord

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Application of Single-Cell Genomics in Cardiovascular Research

Yang

Cao

2023

Cardiol Ther

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Cardiovascular diseases (CVDs) are the leading cause of death in the global world. The emergence of single-cell technologies has greatly facilitated the research on CVDs. Currently, those single-cell technologies have been widely applied in atherosclerosis, myocardial infarction, cardiac ischemia-reperfusion injury, arrhythmia, hypertrophy cardiomyopathy, and heart failure, which are extremely helpful in elucidating the underlying mechanisms of CVDs from physiological and pathological perspectives at DNA, RNA, protein, post-transcriptional, post-translational, and metabolite levels.In this review, we would like to briefly introduce the current single-cell technologies, and will focus on the utilization of single-cell genomics in various heart diseases. Single-cell technologies have great potential in exploration of CVDs, and widespread application of singlecell genomics will promote the understanding and therapeutic treatments for CVDs.

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Clinical Applications of Pluripotent Stem Cells and Their Derivatives: Current Status and Future Perspectives

2022

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Pluripotent stem cells (PSCs) can differentiate into specific cell types and thus hold great promise in regenerative medicine to treat certain diseases. Hence, several studies have been performed harnessing their salutary properties in regenerative medicine. Despite several challenges associated with the clinical applications of PSCs, worldwide efforts are harnessing their potential in the regeneration of damaged tissues. Several clinical trials have been performed using PSCs or their derivatives. However, the delay in publishing the data obtained in the trials has led to a lack of awareness about their outcomes, resulting in apprehension about cellular therapies. Here, the authors review the published papers containing data from recent clinical trials done with PSCs. PSC-derived extracellular vesicles hold great potential in regenerative therapy. Since published papers containing the data obtained in clinical trials on PSC-derived extracellular vesicles are not available yet, the authors have reviewed some of the pre-clinical work done with them.

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Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now

Cited by 5 publications

References 128 publications

Functional genomics in stroke: current and future applications of iPSCs and gene editing to dissect the function of risk variants

Functional genomics in stroke: current and future applications of iPSCs and gene editing to dissect the function of risk variants

Application of Single-Cell Genomics in Cardiovascular Research

Clinical Applications of Pluripotent Stem Cells and Their Derivatives: Current Status and Future Perspectives

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